Nuclear Factor Kappa B2 (NFkB2)

LYT-10; H2TF1; Lymphocyte translocation chromosome 10; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 2(p49/P100); Nuclear factor NF-kappa-B p52

SPN	V016
HGNC	7795
MGI	1099800
PubMed	24140114
RGD	1307189
UniProt	Q00653
Wiki	NFKB2

Nuclear factor NF-kappa-B p100 subunit is a protein encoded by the NFKB2 gene.NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.

Reference

"Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65."
Nature 352:733-736(1991) [PubMed] [Europe PMC] [Abstract]

"A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site."
Mol. Cell. Biol. 12:685-695(1992) [PubMed] [Europe PMC] [Abstract]

"Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells."
Oncogene 9:2335-2344(1994) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Transcriptional regulation of NF-kappa B2: evidence for kappa B-mediated positive and negative autoregulation."
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"Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene."
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"The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers."
Cell 72:729-739(1993) [PubMed] [Europe PMC] [Abstract]

"Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity."
EMBO J. 13:4608-4616(1994) [PubMed] [Europe PMC] [Abstract]

"Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor."
Oncogene 9:1487-1492(1994) [PubMed] [Europe PMC] [Abstract]

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Mol. Cell. Biol. 17:6184-6190(1997) [PubMed] [Europe PMC] [Abstract]

"The generation of nfkb2 p52: mechanism and efficiency."
Oncogene 18:6201-6208(1999) [PubMed] [Europe PMC] [Abstract]

"Differential regulation of NF-kappaB2(p100) processing and control by amino-terminal sequences."
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"B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50."
Cell 67:1075-1087(1991) [PubMed] [Europe PMC] [Abstract]

"Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies."
Blood 84:3850-3860(1994) [PubMed] [Europe PMC] [Abstract]

"Structural and functional characterization of the promoter regions of the NFKB2 gene."
Nucleic Acids Res. 23:2328-2336(1995) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation."
Oncogene 20:4917-4925(2001) [PubMed] [Europe PMC] [Abstract]

"Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase."
Oncogene 23:2540-2547(2004) [PubMed] [Europe PMC] [Abstract]

"IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation."
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"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Germline mutations in NFKB2 implicate the noncanonical NF-kappaB pathway in the pathogenesis of common variable immunodeficiency."
Am. J. Hum. Genet. 93:812-824(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1-A resolution."
EMBO J. 16:7078-7090(1997) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the death domain of nuclear factor NF-kappa-B p100."
Submitted (DEC-2006) to the PDB data bank