Complement Factor D (CFD)

CF-D; DF; PFD; ADN; Adipsin; Properdin Factor D; C3 convertase activator

SPN	V008
HGNC	2771
MGI	87931
PubMed	1374388
RGD	2498
UniProt	P00746
Wiki	Factor_D

Factor D isa member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.

Factor D is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis.The level of Factor D is elevated in the obese, this elevation may be due to high activity or resistance but exact cause is not totally known.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue."
J. Biol. Chem. 267:9210-9213(1992) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of human D of the alternative complement pathway."
Biochemistry 23:2482-2486(1984) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of human factor D of the complement system. Similarity in sequence between factor D and proteases of non-plasma origin."
FEBS Lett. 166:347-351(1984) [PubMed] [Europe PMC] [Abstract]

"Partial amino acid sequence of human factor D: homology with serine proteases."
Proc. Natl. Acad. Sci. U.S.A. 77:1116-1119(1980) [PubMed] [Europe PMC] [Abstract]

"Active site amino acid sequence of human factor D."
Proc. Natl. Acad. Sci. U.S.A. 77:4938-4942(1980) [PubMed] [Europe PMC] [Abstract]

"Factor D of the alternative pathway of human complement. Purification, alignment and N-terminal amino acid sequences of the major cyanogen bromide fragments, and localization of the serine residue at the active site."
Biochem. J. 187:863-874(1980) [PubMed] [Europe PMC] [Abstract]

"Resveratrol-induced changes of the human adipocyte secretion profile."
J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]

"Structure of human factor D. A complement system protein at 2.0-A resolution."
J. Mol. Biol. 235:695-708(1994) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of a complement factor D mutant expressing enhanced catalytic activity."
J. Biol. Chem. 270:24399-24405(1995) [PubMed] [Europe PMC] [Abstract]

"Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections."
Blood 107:4865-4870(2006) [PubMed] [Europe PMC] [Abstract]