Interleukin 2 Receptor Alpha (IL2Ra)
CD25; IL2R-a; IL2-RA; IDDM10; IL2R; TCGFR; p55; TAC antigen
CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2.CD25 expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression.
Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV004Hu01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV004Hu01 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
| PAV004Hu01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV004Hu01 | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA assay for Antigen Detection |
| ELV004Hu01 | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV004Mu01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV004Mu01 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
| PAV004Mu01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV004Mu01 | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA assay for Antigen Detection |
| ELV004Mu01 | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV004Ra01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV004Ra01 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
| PAV004Ra01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV004Ra01 | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA assay for Antigen Detection |
| ELV004Ra01 | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV004Ca01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV004Ca01 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
| PAV004Ca01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV004Ca01 | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA assay for Antigen Detection |
| ELV004Ca01 | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV004Po01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV004Po01 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
| PAV004Po01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV004Po01 | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA assay for Antigen Detection |
| ELV004Po01 | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV004Bo01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV004Bo01 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
| PAV004Bo01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV004Bo01 | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA assay for Antigen Detection |
| ELV004Bo01 | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV004Rb01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV004Rb01 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
| PAV004Rb01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV004Rb01 | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA assay for Antigen Detection |
| ELV004Rb01 | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV004Mo01 | Recombinant Interleukin 2 Receptor Alpha (IL2Ra) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV004Mo01 | Monoclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IP. |
| PAV004Mo01 | Polyclonal Antibody to Interleukin 2 Receptor Alpha (IL2Ra) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV004Mo01 | CLIA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | CLIA assay for Antigen Detection |
| ELV004Mo01 | ELISA Kit for Interleukin 2 Receptor Alpha (IL2Ra) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of cDNA encoding human interleukin-2 receptor."
Nature 311:631-635(1984) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and expression of cDNAs for the human interleukin-2 receptor."
Nature 311:626-631(1984) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and structure of the human interleukin 2 receptor gene."
Nucleic Acids Res. 13:7579-7589(1985) [PubMed] [Europe PMC] [Abstract]
"Structure of the human interleukin-2 receptor gene."
Science 230:633-639(1985) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I."
Cell 49:47-56(1987) [PubMed] [Europe PMC] [Abstract]
"Structural analysis of recombinant soluble human interleukin-2 receptor. Primary structure, assignment of disulfide bonds and core IL-2 binding structure."
Biochem. Biophys. Res. Commun. 154:372-379(1988) [PubMed] [Europe PMC] [Abstract]
"The interleukin-2 and interleukin-4 receptors studied by molecular modelling."
Structure 2:839-851(1994) [PubMed] [Europe PMC] [Abstract]
"Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."
Science 310:1159-1163(2005) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor."
Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006) [PubMed] [Europe PMC] [Abstract]
"Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes."
Nat. Genet. 39:1074-1082(2007) [PubMed] [Europe PMC] [Abstract]