Matrix Metalloproteinase 17 (MMP17)

MT4-MMP; MMP4; Membrane-type matrix metalloproteinase 4; Membrane-type-4 matrix metalloproteinase

SPN	U994
HGNC	7163
MGI	1346076
PubMed	10372554
RGD	1311541
UniProt	Q9ULZ9
Wiki	MMP17

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.

The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.In melanocytic cells MMP17 gene expression may be regulated by MITF.

Reference

"Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts."
FEBS Lett. 457:353-356(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma."
Cancer Res. 56:944-949(1996) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain."
J. Biol. Chem. 274:33043-33049(1999) [PubMed] [Europe PMC] [Abstract]

"Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase."
J. Biol. Chem. 274:34260-34266(1999) [PubMed] [Europe PMC] [Abstract]

"Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase."
Biol. Chem. 380:1103-1108(1999) [PubMed] [Europe PMC] [Abstract]