Choline Transporter Like Protein 1 (CTL1)

CD92; CDw92; SLC44A1; CHTL1; SLC44-A1; Solute Carrier Family 44 Member 1

SPN	U982
HGNC	18798
MGI	2140592
PubMed	23948665
UniProt	Q8WWI5
Wiki	SLC44A1

Using an expression cloning approach, Wille et al. (2001) obtained a cDNA encoding CDw92. The deduced 652-amino acid CDw92 protein is 99% identical to the CTL1 protein reported by O'Regan et al. (2000). CDw92 has cytoplasmic N and C termini, 3 potential N-glycosylation sites, and a potential ITIM (immunoglobulin tyrosine-based inhibitory motif). Immunoprecipitation analysis showed that CDw92 is expressed as a 70-kD protein.

Flow cytometric analysis demonstrated expression of CDw92 on almost all B lymphocytes, most T lymphocytes, some NK cells, and some myeloid cell lines tested. Maturation of monocyte/dendritic cells resulted in downregulation of CDw92, and expression could subsequently be upregulated by interleukin-10 (IL10).

Reference

"An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins."
Proc. Natl. Acad. Sci. U.S.A. 97:1835-1840(2000) [PubMed] [Europe PMC] [Abstract]

"Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells."
J. Immunol. 167:5795-5804(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of the family of choline transporter-like proteins and their splice variants."
J. Neurochem. 92:1116-1125(2005) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"The solute carrier 44A1 is a mitochondrial protein and mediates choline transport."
FASEB J. 23:2749-2758(2009) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]