Cluster Of Differentiation 3d (CD3d)

CD3-DELTA; T3D; T-Dell Surface Glycoprotein CD3 Delta Chain; T-cell receptor T3 delta chain

SPN	U969
HGNC	1673
MGI	88331
PubMed	8281523
RGD	2304
UniProt	P04234
Wiki	CD3D

In immunology, the CD3 T-Cell Co-Receptor (CD stands for cluster of differentiation) is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3d is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene.

Reference

"Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex."
Proc. Natl. Acad. Sci. U.S.A. 83:2944-2948(1986) [PubMed] [Europe PMC] [Abstract]

"Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex."
Nature 312:413-418(1984) [PubMed] [Europe PMC] [Abstract]

"T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells."
EMBO J. 5:1245-1252(1986) [PubMed] [Europe PMC] [Abstract]

"PCR isolation and cloning of novel splice variant mRNAs from known drug target genes."
Genomics 83:566-571(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Dephosphorylation of the human T lymphocyte CD3 antigen."
Eur. J. Biochem. 181:55-65(1989) [PubMed] [Europe PMC] [Abstract]

"Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency."
N. Engl. J. Med. 349:1821-1828(2003) [PubMed] [Europe PMC] [Abstract]

"Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry."
Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003) [PubMed] [Europe PMC] [Abstract]

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

"Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3."
J. Clin. Invest. 114:1512-1517(2004) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID."
Pediatr. Transplant. 15:733-741(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment."
Proc. Natl. Acad. Sci. U.S.A. 101:16268-16273(2004) [PubMed] [Europe PMC] [Abstract]