Coagulation Factor VII (F7)
FVII; SPCA; proconvertin; Cothromboplastin; Serum Prothrombin Conversation Accelerator; Stable Factor; Eptacog alfa
The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with tissue factor (TF). Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself.
The most important substrates for FVIIa-TF are Factor X and Factor IX. The action of the factor is impeded by tissue factor pathway inhibitor (TFPI), which is released almost immediately after initiation of coagulation. Factor VII is vitamin K dependent; it is produced in the liver. Use of warfarin or similar anticoagulants impairs its function.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU967Hu01 | Recombinant Coagulation Factor VII (F7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU967Hu01 | Monoclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IP. |
| PAU967Hu01 | Polyclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU967Hu01 | CLIA Kit for Coagulation Factor VII (F7) | CLIA assay for Antigen Detection |
| ELU967Hu01 | ELISA Kit for Coagulation Factor VII (F7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU967Mu01 | Recombinant Coagulation Factor VII (F7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU967Mu01 | Monoclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IP. |
| PAU967Mu01 | Polyclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU967Mu01 | CLIA Kit for Coagulation Factor VII (F7) | CLIA assay for Antigen Detection |
| ELU967Mu01 | ELISA Kit for Coagulation Factor VII (F7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU967Ra01 | Recombinant Coagulation Factor VII (F7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU967Ra01 | Monoclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IP. |
| PAU967Ra01 | Polyclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU967Ra01 | CLIA Kit for Coagulation Factor VII (F7) | CLIA assay for Antigen Detection |
| ELU967Ra01 | ELISA Kit for Coagulation Factor VII (F7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU967Ca01 | Recombinant Coagulation Factor VII (F7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU967Ca01 | Monoclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IP. |
| PAU967Ca01 | Polyclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU967Ca01 | CLIA Kit for Coagulation Factor VII (F7) | CLIA assay for Antigen Detection |
| ELU967Ca01 | ELISA Kit for Coagulation Factor VII (F7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU967Po01 | Recombinant Coagulation Factor VII (F7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU967Po01 | Monoclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IP. |
| PAU967Po01 | Polyclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU967Po01 | CLIA Kit for Coagulation Factor VII (F7) | CLIA assay for Antigen Detection |
| ELU967Po01 | ELISA Kit for Coagulation Factor VII (F7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU967Bo01 | Recombinant Coagulation Factor VII (F7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU967Bo01 | Monoclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IP. |
| PAU967Bo01 | Polyclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU967Bo01 | CLIA Kit for Coagulation Factor VII (F7) | CLIA assay for Antigen Detection |
| ELU967Bo01 | ELISA Kit for Coagulation Factor VII (F7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU967Rb01 | Recombinant Coagulation Factor VII (F7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU967Rb01 | Monoclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IP. |
| PAU967Rb01 | Polyclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU967Rb01 | CLIA Kit for Coagulation Factor VII (F7) | CLIA assay for Antigen Detection |
| ELU967Rb01 | ELISA Kit for Coagulation Factor VII (F7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU967Mo01 | Recombinant Coagulation Factor VII (F7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU967Mo01 | Monoclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IP. |
| PAU967Mo01 | Polyclonal Antibody to Coagulation Factor VII (F7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU967Mo01 | CLIA Kit for Coagulation Factor VII (F7) | CLIA assay for Antigen Detection |
| ELU967Mo01 | ELISA Kit for Coagulation Factor VII (F7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Erratum
Nat. Genet. 23:373-373(1999)
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"A patient homozygous for a Gly354Cys mutation in factor VII that results in severely impaired secretion of the molecule, but not complete deficiency."
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"Phenotypic and genotypic characterization of Factor VII deficiency patients from Western India."
Clin. Chim. Acta 409:106-111(2009) [PubMed] [Europe PMC] [Abstract]
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