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Forkhead Box Protein P3 (FOXP3)

FOX-P3; AIID; DIETER; IPEX; JM2; PIDX; XPID; SCURFIN; Immune Dysregulation,Polyendocrinopathy,Enteropathy,X-Linked

Foxp3 is a member of the forkhead/winged-helix family of transcriptional regulators and functions as the master regulator in the development and function of regulatory T cells. Human FOXP3 genes contain 11 coding exons. Exon-intron boundaries are identical across the coding regions of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to chromosome Xp11.23.
Foxp3 gene is mutated in the X-linked syndrome of immunodysregulation, polyendocrinopathy, and enteropathy (IPEX). These mutations were in the forkhead domain of FOXP3, indicating that the mutations may disrupt critical DNA interactions.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU964Hu01 Recombinant Forkhead Box Protein P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU964Hu01 Monoclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IP.
PAU964Hu01 Polyclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IF.
Assay Kits CLU964Hu01 CLIA Kit for Forkhead Box Protein P3 (FOXP3) CLIA assay for Antigen Detection
ELU964Hu01 ELISA Kit for Forkhead Box Protein P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU964Mu01 Recombinant Forkhead Box Protein P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU964Mu01 Monoclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IP.
PAU964Mu01 Polyclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IF.
Assay Kits CLU964Mu01 CLIA Kit for Forkhead Box Protein P3 (FOXP3) CLIA assay for Antigen Detection
ELU964Mu01 ELISA Kit for Forkhead Box Protein P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU964Ra01 Recombinant Forkhead Box Protein P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU964Ra01 Monoclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IP.
PAU964Ra01 Polyclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IF.
Assay Kits CLU964Ra01 CLIA Kit for Forkhead Box Protein P3 (FOXP3) CLIA assay for Antigen Detection
ELU964Ra01 ELISA Kit for Forkhead Box Protein P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU964Ca01 Recombinant Forkhead Box Protein P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU964Ca01 Monoclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IP.
PAU964Ca01 Polyclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IF.
Assay Kits CLU964Ca01 CLIA Kit for Forkhead Box Protein P3 (FOXP3) CLIA assay for Antigen Detection
ELU964Ca01 ELISA Kit for Forkhead Box Protein P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU964Po01 Recombinant Forkhead Box Protein P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU964Po01 Monoclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IP.
PAU964Po01 Polyclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IF.
Assay Kits CLU964Po01 CLIA Kit for Forkhead Box Protein P3 (FOXP3) CLIA assay for Antigen Detection
ELU964Po01 ELISA Kit for Forkhead Box Protein P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU964Bo01 Recombinant Forkhead Box Protein P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU964Bo01 Monoclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IP.
PAU964Bo01 Polyclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IF.
Assay Kits CLU964Bo01 CLIA Kit for Forkhead Box Protein P3 (FOXP3) CLIA assay for Antigen Detection
ELU964Bo01 ELISA Kit for Forkhead Box Protein P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU964Rb01 Recombinant Forkhead Box Protein P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU964Rb01 Monoclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IP.
PAU964Rb01 Polyclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IF.
Assay Kits CLU964Rb01 CLIA Kit for Forkhead Box Protein P3 (FOXP3) CLIA assay for Antigen Detection
ELU964Rb01 ELISA Kit for Forkhead Box Protein P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU964Mo01 Recombinant Forkhead Box Protein P3 (FOXP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU964Mo01 Monoclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IP.
PAU964Mo01 Polyclonal Antibody to Forkhead Box Protein P3 (FOXP3) WB; IHC; ICC; IF.
Assay Kits CLU964Mo01 CLIA Kit for Forkhead Box Protein P3 (FOXP3) CLIA assay for Antigen Detection
ELU964Mo01 ELISA Kit for Forkhead Box Protein P3 (FOXP3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 102:5138-5143(2005) [PubMed] [Europe PMC] [Abstract]

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Nature 446:685-689(2007) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 104:4571-4576(2007) [PubMed] [Europe PMC] [Abstract]

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J. Immunol. 180:4785-4792(2008) [PubMed] [Europe PMC] [Abstract]

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Nature 453:236-240(2008) [PubMed] [Europe PMC] [Abstract]

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Nat. Immunol. 11:846-853(2010) [PubMed] [Europe PMC] [Abstract]

"Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells."
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J. Immunol. 188:2712-2721(2012) [PubMed] [Europe PMC] [Abstract]

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Blood 121:1265-1275(2013) [PubMed] [Europe PMC] [Abstract]

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Front. Oncol. 3:294-294(2013) [PubMed] [Europe PMC] [Abstract]

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Immunity 39:259-271(2013) [PubMed] [Europe PMC] [Abstract]

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Immunity 39:272-285(2013) [PubMed] [Europe PMC] [Abstract]

"Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28."
J. Immunol. 190:4470-4473(2013) [PubMed] [Europe PMC] [Abstract]

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Nat. Med. 19:322-328(2013) [PubMed] [Europe PMC] [Abstract]

"The role of FOXP3 in regulating immune responses."
Int. Rev. Immunol. 33:110-128(2014) [PubMed] [Europe PMC] [Abstract]

"Forkhead box P3: the peacekeeper of the immune system."
Int. Rev. Immunol. 33:129-145(2014) [PubMed] [Europe PMC] [Abstract]

"FOXP3 and scurfy: how it all began."
Nat. Rev. Immunol. 14:343-349(2014) [PubMed] [Europe PMC] [Abstract]

"Post-translational modification networks regulating FOXP3 function."
Trends Immunol. 35:368-378(2014) [PubMed] [Europe PMC] [Abstract]

"JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome."
J. Clin. Invest. 106:R75-R81(2000) [PubMed] [Europe PMC] [Abstract]

"Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)."
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"X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy."
Nat. Genet. 27:18-20(2001) [PubMed] [Europe PMC] [Abstract]

"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3."
Nat. Genet. 27:20-21(2001) [PubMed] [Europe PMC] [Abstract]