Cyclin Dependent Kinase 1 (CDK1)

CDC2; CDC28A; CDK1; CDC28-A; CDKN1; P34CDC2; p34 protein kinase; Cell Division Control Protein 2 Homolog; Cell Division Cycle 2,G1 To S And G2 To M

SPN	U953
HGNC	1722
MGI	88351
PubMed	22355113
RGD	2319
UniProt	P06493
Wiki	Cdk1

Cell division cycle 2, G1 to S and G2 to M, a catalytic subunit of the highly conserved protein kinase complex known as maturation promoting factor (MPF), which is essential G2/M phase transitions of the mammalian cell cycle. In higher eukaryotes, eg mammals one should note the presence of cdk4,cdk6 and cdk2 as the active kinases in control of the G1/S checkpoint. Mitotic cyclins stably associate with this protein and function as regulatory subunits.

The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.

Reference

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Nature 327:31-35(1987) [PubMed] [Europe PMC] [Abstract]

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Science 270:86-90(1995) [PubMed] [Europe PMC] [Abstract]

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"The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpoint."
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"Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition."
J. Biol. Chem. 285:16978-16990(2010) [PubMed] [Europe PMC] [Abstract]

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Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

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