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Oxidosqualene Cyclase (OSC)

LSS; Lanosterol Synthase; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase

Lanosterol synthase (EC 5.4.99.7) catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol in the reaction that forms the sterol nucleus. Baker et al. (1995) cloned and characterized the human gene encoding lanosterol synthase, which they called OSC, and found that it predicts an 83-kD protein of 732 amino acids. The deduced amino acid sequence is 36 to 40% identical to known yeast and plant homologs and 83% identical to rat lanosterol synthase. A yeast lanosterol synthase-deficient mutant was complemented by the human gene, and a cell-free homogenate of the yeast mutant strain expressed in the human gene was shown to convert 2,3-oxidosqualene to lanosterol.  Oxidosqualene cyclase solves this problem by sticking to the membrane in microsomes inside the cell.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U943Hu01 Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
PU943Hu01 Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U943Ra01 Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
PU943Ra01 Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Oxidosqualene Cyclase (OSC) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Oxidosqualene Cyclase (OSC) Bioactivity
Antibodies NONE Monoclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Oxidosqualene Cyclase (OSC) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Oxidosqualene Cyclase (OSC) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Oxidosqualene Cyclase (OSC) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Oxidosqualene Cyclase (OSC) CLIA assay for Antigen Detection

Reference

"Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library."
Biochem. Biophys. Res. Commun. 213:154-160(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of cDNA encoding human lanosterol synthase."
Biol. Pharm. Bull. 18:1459-1461(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the human lanosterol synthase gene and its analysis as a candidate for holoprosencephaly."
Hum. Genet. 105:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The monotopic membrane protein human oxidosqualene cyclase is active as monomer."
Biochem. Biophys. Res. Commun. 315:247-254(2004) [PubMed] [Europe PMC] [Abstract]

"The human lanosterol synthase gene maps to chromosome 21q22.3."
Hum. Genet. 97:620-624(1996) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase."
Nature 432:118-122(2004) [PubMed] [Europe PMC] [Abstract]