Interferon Gamma Inducible Protein 16 (IFI16)

IFI16; IFNGIP1; PYHIN2; Interferon-inducible myeloid differentiation transcriptional activator

SPN	U941
HGNC	5395
MGI	96429
PubMed	20890285
RGD	1306089
UniProt	Q16666
Wiki	IFI16

Gamma-interferon-inducible protein Ifi-16 is a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.At least 6 interferon-gamma-inducible genes located on mouse chromosome 1 were described by Choubey et al., Kingsmore et al., and others. In the mouse, the genes mapped to a 150-kb segment of DNA, and the serum amyloid P component gene (Sap) mapped within approximately 450 kb of the IFN-inducible gene cluster.

Reference

"A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells."
Immunogenetics 36:369-376(1992) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization."
Immunogenetics 40:415-424(1994) [PubMed] [Europe PMC] [Abstract]

"Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence."
Oncogene 22:4831-4840(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing."
Biochemistry 37:11924-11931(1998) [PubMed] [Europe PMC] [Abstract]

"IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines."
J. Cell. Biochem. 57:39-51(1995) [PubMed] [Europe PMC] [Abstract]

"The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression."
Immunogenetics 41:40-43(1995) [PubMed] [Europe PMC] [Abstract]

"The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations."
J. Leukoc. Biol. 64:546-554(1998) [PubMed] [Europe PMC] [Abstract]

"The human interferon-inducible protein, IFI 16, is a repressor of transcription."
J. Biol. Chem. 273:17172-17177(1998) [PubMed] [Europe PMC] [Abstract]

"Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16."
Oncogene 19:6033-6042(2000) [PubMed] [Europe PMC] [Abstract]

"A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway."
Oncogene 22:8931-8938(2003) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]

"IFI16 is an innate immune sensor for intracellular DNA."
Nat. Immunol. 11:997-1004(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection."
Cell Host Microbe 9:363-375(2011) [PubMed] [Europe PMC] [Abstract]

"IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway."
PLoS ONE 6:E19532-E19532(2011) [PubMed] [Europe PMC] [Abstract]

"IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes."
PLoS ONE 6:E27040-E27040(2011) [PubMed] [Europe PMC] [Abstract]

"Preferential binding of IFI16 protein to cruciform structure and superhelical DNA."
Biochem. Biophys. Res. Commun. 422:716-720(2012) [PubMed] [Europe PMC] [Abstract]

"The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication."
PLoS Pathog. 8:E1002498-E1002498(2012) [PubMed] [Europe PMC] [Abstract]

"Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein."
Proc. Natl. Acad. Sci. U.S.A. 109:E3008-E3017(2012) [PubMed] [Europe PMC] [Abstract]

"Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16."
Proc. Natl. Acad. Sci. U.S.A. 109:10558-10563(2012) [PubMed] [Europe PMC] [Abstract]

"Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA."
Proc. Natl. Acad. Sci. U.S.A. 110:E4492-E4501(2013) [PubMed] [Europe PMC] [Abstract]

"Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."
Cancer Res. 74:1484-1494(2014) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53."
Structure 19:418-429(2011) [PubMed] [Europe PMC] [Abstract]

"Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor."
Immunity 36:561-571(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the first HIN-200 domain of interferon-inducible protein 16."
Submitted (FEB-2007) to the PDB data bank

"Crystal structure analysis of the second HIN domain of IFI16."
Submitted (NOV-2007) to the PDB data bank