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Ficolin 2 (FCN2)

EBP37; FCNL; P35; Hucolin; 37 kDa elastin-binding protein; Collagen/Fibrinogen Domain Containing Lectin; Ficolin B; Serum Lectin p35; L-Ficolin

Ficolin-2 belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.

Serum concentration of ficolin-2 varies considerably in healthy individuals.FCN2 promoter polymorphisms were associated with marked changes in the ficolin-2 serum concentration, whereas 2 nonsynonymous SNPs clustered in exon 8 encoding the fibrinogen-like domain were associated with decreased and increased GlcNAc binding, respectively.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU934Hu01 Recombinant Ficolin 2 (FCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU934Hu01 Monoclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IP.
PAU934Hu01 Polyclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IF.
Assay Kits CLU934Hu01 CLIA Kit for Ficolin 2 (FCN2) CLIA assay for Antigen Detection
ELU934Hu01 ELISA Kit for Ficolin 2 (FCN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU934Mu01 Recombinant Ficolin 2 (FCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU934Mu01 Monoclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IP.
PAU934Mu01 Polyclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IF.
Assay Kits CLU934Mu01 CLIA Kit for Ficolin 2 (FCN2) CLIA assay for Antigen Detection
ELU934Mu01 ELISA Kit for Ficolin 2 (FCN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU934Ra01 Recombinant Ficolin 2 (FCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU934Ra01 Monoclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IP.
PAU934Ra01 Polyclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IF.
Assay Kits CLU934Ra01 CLIA Kit for Ficolin 2 (FCN2) CLIA assay for Antigen Detection
ELU934Ra01 ELISA Kit for Ficolin 2 (FCN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU934Ca01 Recombinant Ficolin 2 (FCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU934Ca01 Monoclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IP.
PAU934Ca01 Polyclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IF.
Assay Kits CLU934Ca01 CLIA Kit for Ficolin 2 (FCN2) CLIA assay for Antigen Detection
ELU934Ca01 ELISA Kit for Ficolin 2 (FCN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU934Po01 Recombinant Ficolin 2 (FCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU934Po01 Monoclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IP.
PAU934Po01 Polyclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IF.
Assay Kits CLU934Po01 CLIA Kit for Ficolin 2 (FCN2) CLIA assay for Antigen Detection
ELU934Po01 ELISA Kit for Ficolin 2 (FCN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU934Bo01 Recombinant Ficolin 2 (FCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU934Bo01 Monoclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IP.
PAU934Bo01 Polyclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IF.
Assay Kits CLU934Bo01 CLIA Kit for Ficolin 2 (FCN2) CLIA assay for Antigen Detection
ELU934Bo01 ELISA Kit for Ficolin 2 (FCN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU934Rb01 Recombinant Ficolin 2 (FCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU934Rb01 Monoclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IP.
PAU934Rb01 Polyclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IF.
Assay Kits CLU934Rb01 CLIA Kit for Ficolin 2 (FCN2) CLIA assay for Antigen Detection
ELU934Rb01 ELISA Kit for Ficolin 2 (FCN2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU934Mo01 Recombinant Ficolin 2 (FCN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU934Mo01 Monoclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IP.
PAU934Mo01 Polyclonal Antibody to Ficolin 2 (FCN2) WB; IHC; ICC; IF.
Assay Kits CLU934Mo01 CLIA Kit for Ficolin 2 (FCN2) CLIA assay for Antigen Detection
ELU934Mo01 ELISA Kit for Ficolin 2 (FCN2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and characterization of the human lectin P35 gene and its related gene."
Genomics 36:515-521(1996) [PubMed] [Europe PMC] [Abstract]

"A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin."
J. Biol. Chem. 271:2448-2454(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins."
FEBS Lett. 375:159-161(1995) [PubMed] [Europe PMC] [Abstract]

"EBP-37, a new elastin-binding protein in human plasma: structural similarity to ficolins, transforming growth factor-beta 1-binding proteins."
J. Biochem. 117:1029-1035(1995) [PubMed] [Europe PMC] [Abstract]

"Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease."
J. Immunol. 164:2281-2284(2000) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]