Aggrecan (AGC)
ACAN; AGC1; AGCAN; CSPG1; CSPCP; CSPGCP; MSK16; SEDK; Cartilage-specific proteoglycan core protein; Large Aggregating Proteoglycan; Chondroitin Sulfate Proteoglycan 1
Aggrecan, or large aggregating proteoglycan, is a proteoglycan, or a protein modified with carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing. Along with Type-II collagen, aggrecan forms a major structural component of cartilage, particularly articular cartilage.
Aggrecan consists of two globular structural domains at the N-terminal end and one globular domain at the C-terminal end, separated by a large domain heavily modified with glycosaminoglycans. The two main modifier moieties are themselves arranged into distinct regions, a chondroitin sulfate and a keratan sulfate region.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU933Hu01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU933Hu01 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAU933Hu01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU933Hu01 | CLIA Kit for Aggrecan (AGC) | CLIA assay for Antigen Detection |
| ELU933Hu01 | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU933Mu01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU933Mu01 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAU933Mu01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU933Mu01 | CLIA Kit for Aggrecan (AGC) | CLIA assay for Antigen Detection |
| ELU933Mu01 | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU933Ra01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU933Ra01 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAU933Ra01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU933Ra01 | CLIA Kit for Aggrecan (AGC) | CLIA assay for Antigen Detection |
| ELU933Ra01 | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU933Ca01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU933Ca01 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAU933Ca01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU933Ca01 | CLIA Kit for Aggrecan (AGC) | CLIA assay for Antigen Detection |
| ELU933Ca01 | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU933Po01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU933Po01 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAU933Po01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU933Po01 | CLIA Kit for Aggrecan (AGC) | CLIA assay for Antigen Detection |
| ELU933Po01 | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU933Bo01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU933Bo01 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAU933Bo01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU933Bo01 | CLIA Kit for Aggrecan (AGC) | CLIA assay for Antigen Detection |
| ELU933Bo01 | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU933Rb01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU933Rb01 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAU933Rb01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU933Rb01 | CLIA Kit for Aggrecan (AGC) | CLIA assay for Antigen Detection |
| ELU933Rb01 | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU933Mo01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU933Mo01 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAU933Mo01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU933Mo01 | CLIA Kit for Aggrecan (AGC) | CLIA assay for Antigen Detection |
| ELU933Mo01 | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms."
J. Biol. Chem. 266:894-902(1991) [PubMed] [Europe PMC] [Abstract]
"Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid."
Arch. Biochem. Biophys. 322:22-30(1995) [PubMed] [Europe PMC] [Abstract]
"The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain."
J. Clin. Invest. 89:1512-1516(1992) [PubMed] [Europe PMC] [Abstract]
"Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes."
Biochim. Biophys. Acta 1219:613-622(1994) [PubMed] [Europe PMC] [Abstract]
"The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis."
Arthritis Rheum. 36:1214-1222(1993) [PubMed] [Europe PMC] [Abstract]
"Length variation in the keratan sulfate domain of mammalian aggrecan."
Matrix Biol. 14:323-328(1994) [PubMed] [Europe PMC] [Abstract]
"Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage."
Biochem. J. 313:933-940(1996) [PubMed] [Europe PMC] [Abstract]
"A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain."
J. Biol. Chem. 264:15747-15750(1989) [PubMed] [Europe PMC] [Abstract]
"A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis."
Am. J. Hum. Genet. 77:484-490(2005) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan."
J. Biol. Chem. 282:24591-24598(2007) [PubMed] [Europe PMC] [Abstract]
"A recessive skeletal dysplasia, SEMD aggrecan type, results from a missense mutation affecting the C-type lectin domain of aggrecan."
Am. J. Hum. Genet. 84:72-79(2009) [PubMed] [Europe PMC] [Abstract]
"A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans."
Am. J. Hum. Genet. 86:126-137(2010) [PubMed] [Europe PMC] [Abstract]