p53 Upregulated Modulator Of Apoptosis (PUMA)
JFY1; BBC3; BCL2 Binding Component 3
The p53 upregulated modulator of apoptosis, or PUMA, is a pro-apoptotic member of the Bcl-2 protein family.Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and PUMA has been shown to be involved in p53-mediated apoptosis.Genomic sequence analysis revealed that the PUMA transcript is contained within 4 exons, with the presumptive initiation codon in exon 2. The predicted 193-amino acid PUMA protein shares 91% amino acid identity with the murine sequence. PUMA protein is exclusively mitochondrial and binds to BCL2 and BCLXL through a BH3 domain.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU932Hu01 | Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU932Hu01 | Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IP. |
| PAU932Hu01 | Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU932Hu01 | CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | CLIA assay for Antigen Detection |
| ELU932Hu01 | ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU932Mu01 | Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU932Mu01 | Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IP. |
| PAU932Mu01 | Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU932Mu01 | CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | CLIA assay for Antigen Detection |
| ELU932Mu01 | ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU932Ra01 | Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU932Ra01 | Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IP. |
| PAU932Ra01 | Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU932Ra01 | CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | CLIA assay for Antigen Detection |
| ELU932Ra01 | ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU932Ca01 | Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU932Ca01 | Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IP. |
| PAU932Ca01 | Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU932Ca01 | CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | CLIA assay for Antigen Detection |
| ELU932Ca01 | ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU932Po01 | Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU932Po01 | Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IP. |
| PAU932Po01 | Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU932Po01 | CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | CLIA assay for Antigen Detection |
| ELU932Po01 | ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU932Bo01 | Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU932Bo01 | Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IP. |
| PAU932Bo01 | Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU932Bo01 | CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | CLIA assay for Antigen Detection |
| ELU932Bo01 | ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU932Rb01 | Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU932Rb01 | Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IP. |
| PAU932Rb01 | Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU932Rb01 | CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | CLIA assay for Antigen Detection |
| ELU932Rb01 | ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU932Mo01 | Recombinant p53 Upregulated Modulator Of Apoptosis (PUMA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU932Mo01 | Monoclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IP. |
| PAU932Mo01 | Polyclonal Antibody to p53 Upregulated Modulator Of Apoptosis (PUMA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU932Mo01 | CLIA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | CLIA assay for Antigen Detection |
| ELU932Mo01 | ELISA Kit for p53 Upregulated Modulator Of Apoptosis (PUMA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"PUMA induces the rapid apoptosis of colorectal cancer cells."
Mol. Cell 7:673-682(2001) [PubMed] [Europe PMC] [Abstract]
"PUMA, a novel proapoptotic gene, is induced by p53."
Mol. Cell 7:683-694(2001) [PubMed] [Europe PMC] [Abstract]
"Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals."
Proc. Natl. Acad. Sci. U.S.A. 98:11318-11323(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress."
PLoS ONE 7:E39586-E39586(2012) [PubMed] [Europe PMC] [Abstract]
"PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis."
Nat. Chem. Biol. 9:163-168(2013) [PubMed] [Europe PMC] [Abstract]