Kallikrein 7 (KLK7)

PRSS6; SCCE; hK7; Kallikrein-Related Peptidase 7; Serine protease 6; Stratum corneum chymotryptic enzyme

SPN	U931
HGNC	6368
MGI	1346336
PubMed	14691584
RGD	1306420
UniProt	P49862
Wiki	KLK7

Kallikrein-related peptidase 7, also known as KLK7, Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded enzyme is thought to be involved in the proteolysis of intercellular cohesive structures preceding desquamation, which is the shedding of the outermost layer of the epidermis. Alternative splicing of this gene results in two transcript variants encoding the same protein.

Reference

"Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase."
J. Biol. Chem. 269:19420-19426(1994) [PubMed] [Europe PMC] [Abstract]

"The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation."
Gene 254:119-128(2000) [PubMed] [Europe PMC] [Abstract]

"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]

"Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis."
J. Invest. Dermatol. 118:444-449(2002) [PubMed] [Europe PMC] [Abstract]

"Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers."
Clin. Cancer Res. 9:1710-1720(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme."
Biochem. Biophys. Res. Commun. 211:586-589(1995) [PubMed] [Europe PMC] [Abstract]

"Vaspin inhibits kallikrein 7 by serpin mechanism."
Cell. Mol. Life Sci. 70:2569-2583(2013) [PubMed] [Europe PMC] [Abstract]

"Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7."
Proc. Natl. Acad. Sci. U.S.A. 104:16086-16091(2007) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6)."
J. Mol. Biol. 377:1488-1497(2008) [PubMed] [Europe PMC] [Abstract]