Cholinergic Receptor, Nicotinic, Alpha 2 (CHRNa2)

CHR-NA2; CHRN-A2; N-AChRA2; NAChRA2; N-AChR-A2; Neuronal Acetylcholine Receptor Alpha 2

SPN	U915
HGNC	1956
MGI	87886
PubMed	23637165
RGD	621533
UniProt	Q15822
Wiki	CHRNA2

Elliott et al. (1996) cloned CHRNA2 from a thalamus cDNA library following low-stringency screening with the rat alpha-4-1 probe. The deduced 503-amino acid protein has a calculated molecular mass of 56.9 kD and contains a signal peptide, 3 N-glycosylation sites, and 4 transmembrane regions. The human and rat proteins share 84% sequence identity.Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, Dorus et al. (2004) examined the evolution of genes involved in diverse aspects of nervous system biology. These genes, including CHRNA2, displayed significantly higher rates of protein evolution in primates than in rodents. This trend was most pronounced for the subset of genes implicated in nervous system development.

Reference

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J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Increased sensitivity of the neuronal nicotinic receptor alpha2 subunit causes familial epilepsy with nocturnal wandering and ictal fear."
Am. J. Hum. Genet. 79:342-350(2006) [PubMed] [Europe PMC] [Abstract]