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Fumarase (FUM)

FH; Fumarate Hydratase, mitochondrial

Fumarase (or fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of Fumarate to S-malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs Cycle (also known as the Citric Acid Cycle), and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular localization is established by the presence of a signal sequence on the amino terminus in the mitochondrial form, while subcellular localization in the cytosolic form is established by the abence of the signal sequence found in the mitochondrial variety. This enzyme participates in 3 metabolic pathways: citric acid cycle, reductive carboxylation cycle (CO2 fixation), and in renal cell carcinoma.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU910Hu01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU910Hu01 Monoclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IP.
PAU910Hu01 Polyclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IF.
Assay Kits CLU910Hu01 CLIA Kit for Fumarase (FUM) CLIA assay for Antigen Detection
ELU910Hu01 ELISA Kit for Fumarase (FUM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU910Mu01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU910Mu01 Monoclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IP.
PAU910Mu01 Polyclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IF.
Assay Kits CLU910Mu01 CLIA Kit for Fumarase (FUM) CLIA assay for Antigen Detection
ELU910Mu01 ELISA Kit for Fumarase (FUM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU910Ra01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU910Ra01 Monoclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IP.
PAU910Ra01 Polyclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IF.
Assay Kits CLU910Ra01 CLIA Kit for Fumarase (FUM) CLIA assay for Antigen Detection
ELU910Ra01 ELISA Kit for Fumarase (FUM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU910Ca01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU910Ca01 Monoclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IP.
PAU910Ca01 Polyclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IF.
Assay Kits CLU910Ca01 CLIA Kit for Fumarase (FUM) CLIA assay for Antigen Detection
ELU910Ca01 ELISA Kit for Fumarase (FUM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU910Po01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU910Po01 Monoclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IP.
PAU910Po01 Polyclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IF.
Assay Kits CLU910Po01 CLIA Kit for Fumarase (FUM) CLIA assay for Antigen Detection
ELU910Po01 ELISA Kit for Fumarase (FUM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU910Bo01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU910Bo01 Monoclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IP.
PAU910Bo01 Polyclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IF.
Assay Kits CLU910Bo01 CLIA Kit for Fumarase (FUM) CLIA assay for Antigen Detection
ELU910Bo01 ELISA Kit for Fumarase (FUM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU910Rb01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU910Rb01 Monoclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IP.
PAU910Rb01 Polyclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IF.
Assay Kits CLU910Rb01 CLIA Kit for Fumarase (FUM) CLIA assay for Antigen Detection
ELU910Rb01 ELISA Kit for Fumarase (FUM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU910Mo01 Recombinant Fumarase (FUM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU910Mo01 Monoclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IP.
PAU910Mo01 Polyclonal Antibody to Fumarase (FUM) WB; IHC; ICC; IF.
Assay Kits CLU910Mo01 CLIA Kit for Fumarase (FUM) CLIA assay for Antigen Detection
ELU910Mo01 ELISA Kit for Fumarase (FUM) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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Biosci. Rep. 6:921-929(1986) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2007) to UniProtKB

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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human fumarate hydratase."
Submitted (DEC-2012) to the PDB data bank

"Identification of a molecular defect in a fumarase deficient patient and mapping of the fumarase gene."
Am. J. Hum. Genet. 53:A896-A896(1993)

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Mol. Genet. Metab. 63:254-262(1998) [PubMed] [Europe PMC] [Abstract]

"Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer."
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