Cathepsin S (CTSS)

CTS-S

SPN	U908
HGNC	2545
MGI	107341
PubMed	12164923
RGD	621513
UniProt	P25774
Wiki	Cathepsin_S

CTSS is a member of the peptidase C1 family, is a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages.

Cathepsin S has been shown to be a significant prognostic factor for patients with type IV astrocytomas (glioblastoma multiforme) and its inhibition has shown improvement in survival time by mean average 5 months. This is because the cysteine enzyme can no longer act together with other proteases to break up the brain extracellular matrix. So the spread of the tumor is halted.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U908Hu01	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	MU908Hu22	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	PU908Hu01	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	KEU908Hu	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U908Mu01	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	PU908Mu01	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	LU908Mu81	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	KEU908Mu	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U908Ra01	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	MU908Ra21	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	PU908Ra01	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U908Bo01	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	PU908Bo01	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin S (CTSS)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin S (CTSS)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin S (CTSS)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin S (CTSS)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin S (CTSS)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin S (CTSS)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin S (CTSS)	CLIA assay for Antigen Detection

Reference

"Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease."
J. Biol. Chem. 267:7258-7262(1992) [PubMed] [Europe PMC] [Abstract]

"Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S."
J. Biol. Chem. 267:13708-13713(1992) [PubMed] [Europe PMC] [Abstract]

"Human cathepsin S: chromosomal localization, gene structure, and tissue distribution."
J. Biol. Chem. 269:11530-11536(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics."
Protein Eng. 11:1007-1013(1998) [PubMed] [Europe PMC] [Abstract]

"Structure of a Cys25-->Ser mutant of human cathepsin S."
Acta Crystallogr. D 58:451-455(2002) [PubMed] [Europe PMC] [Abstract]

"Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode."
J. Med. Chem. 50:2693-2699(2007) [PubMed] [Europe PMC] [Abstract]