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Tenascin X (TNX)

TN-X; TNXB; TNX-B; TNXA; TNX-A; TNXB1; TNXB2; HXBL; Hexabrachion-like protein

Tenascin X is a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU906Hu01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU906Hu01 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
PAU906Hu01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IF.
Assay Kits CLU906Hu01 CLIA Kit for Tenascin X (TNX) CLIA assay for Antigen Detection
ELU906Hu01 ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU906Mu01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU906Mu01 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
PAU906Mu01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IF.
Assay Kits CLU906Mu01 CLIA Kit for Tenascin X (TNX) CLIA assay for Antigen Detection
ELU906Mu01 ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU906Ra01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU906Ra01 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
PAU906Ra01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IF.
Assay Kits CLU906Ra01 CLIA Kit for Tenascin X (TNX) CLIA assay for Antigen Detection
ELU906Ra01 ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU906Ca01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU906Ca01 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
PAU906Ca01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IF.
Assay Kits CLU906Ca01 CLIA Kit for Tenascin X (TNX) CLIA assay for Antigen Detection
ELU906Ca01 ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU906Po01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU906Po01 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
PAU906Po01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IF.
Assay Kits CLU906Po01 CLIA Kit for Tenascin X (TNX) CLIA assay for Antigen Detection
ELU906Po01 ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU906Bo01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU906Bo01 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
PAU906Bo01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IF.
Assay Kits CLU906Bo01 CLIA Kit for Tenascin X (TNX) CLIA assay for Antigen Detection
ELU906Bo01 ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU906Rb01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU906Rb01 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
PAU906Rb01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IF.
Assay Kits CLU906Rb01 CLIA Kit for Tenascin X (TNX) CLIA assay for Antigen Detection
ELU906Rb01 ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU906Mo01 Recombinant Tenascin X (TNX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU906Mo01 Monoclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IP.
PAU906Mo01 Polyclonal Antibody to Tenascin X (TNX) WB; IHC; ICC; IF.
Assay Kits CLU906Mo01 CLIA Kit for Tenascin X (TNX) CLIA assay for Antigen Detection
ELU906Mo01 ELISA Kit for Tenascin X (TNX) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X."
Genomics 28:171-178(1995) [PubMed] [Europe PMC] [Abstract]

"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B."
J. Cell Biol. 122:265-278(1993) [PubMed] [Europe PMC] [Abstract]

"Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes."
Hum. Mol. Genet. 5:1749-1758(1996) [PubMed] [Europe PMC] [Abstract]

"Cluster of fibronectin type III repeats found in the human major histocompatibility complex class III region shows the highest homology with the repeats in an extracellular matrix protein, tenascin."
Genomics 12:485-491(1992) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of multiple species of tenascin-X in human serum."
FEBS J. 274:1280-1289(2007) [PubMed] [Europe PMC] [Abstract]

"Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus."
Proc. Natl. Acad. Sci. U.S.A. 86:6582-6586(1989) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Interactions of human tenascin-X domains with dermal extracellular matrix molecules."
Arch. Dermatol. Res. 298:389-396(2007) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the 29th, 31st and 33rd fibronectin type-III domains of the human tenascin-X."
Submitted (NOV-2005) to the PDB data bank

"A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency."
N. Engl. J. Med. 345:1167-1175(2001) [PubMed] [Europe PMC] [Abstract]

"Elastic fiber abnormalities in hypermobility type Ehlers-Danlos syndrome patients with tenascin-X mutations."
Clin. Genet. 67:330-334(2005) [PubMed] [Europe PMC] [Abstract]

"Compound heterozygous mutations of the TNXB gene cause primary myopathy."
Neuromuscul. Disord. 23:664-669(2013) [PubMed] [Europe PMC] [Abstract]

"TNXB mutations can cause vesicoureteral reflux."
J. Am. Soc. Nephrol. 24:1313-1322(2013) [PubMed] [Europe PMC] [Abstract]