Melanoma Antigen Family A1 (MAGEA1)
MAGE1; CT1.1; Melanoma-Associated Antigen 1; Cancer/Testis Antigen Family 1 Member 1; Antigen MZ2-E
MAGEA1 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.
The gene showed no similarity to known sequences. It was expressed by the original melanoma cells, by other melanoma cell lines, and by some tumor cells of other histologic types. No expression was observed in a panel of normal tissues.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU905Hu01 | Recombinant Melanoma Antigen Family A1 (MAGEA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU905Hu01 | Monoclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IP. |
| PAU905Hu01 | Polyclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU905Hu01 | CLIA Kit for Melanoma Antigen Family A1 (MAGEA1) | CLIA assay for Antigen Detection |
| ELU905Hu01 | ELISA Kit for Melanoma Antigen Family A1 (MAGEA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU905Mu01 | Recombinant Melanoma Antigen Family A1 (MAGEA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU905Mu01 | Monoclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IP. |
| PAU905Mu01 | Polyclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU905Mu01 | CLIA Kit for Melanoma Antigen Family A1 (MAGEA1) | CLIA assay for Antigen Detection |
| ELU905Mu01 | ELISA Kit for Melanoma Antigen Family A1 (MAGEA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU905Ra01 | Recombinant Melanoma Antigen Family A1 (MAGEA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU905Ra01 | Monoclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IP. |
| PAU905Ra01 | Polyclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU905Ra01 | CLIA Kit for Melanoma Antigen Family A1 (MAGEA1) | CLIA assay for Antigen Detection |
| ELU905Ra01 | ELISA Kit for Melanoma Antigen Family A1 (MAGEA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU905Ca01 | Recombinant Melanoma Antigen Family A1 (MAGEA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU905Ca01 | Monoclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IP. |
| PAU905Ca01 | Polyclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU905Ca01 | CLIA Kit for Melanoma Antigen Family A1 (MAGEA1) | CLIA assay for Antigen Detection |
| ELU905Ca01 | ELISA Kit for Melanoma Antigen Family A1 (MAGEA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU905Po01 | Recombinant Melanoma Antigen Family A1 (MAGEA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU905Po01 | Monoclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IP. |
| PAU905Po01 | Polyclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU905Po01 | CLIA Kit for Melanoma Antigen Family A1 (MAGEA1) | CLIA assay for Antigen Detection |
| ELU905Po01 | ELISA Kit for Melanoma Antigen Family A1 (MAGEA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU905Bo01 | Recombinant Melanoma Antigen Family A1 (MAGEA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU905Bo01 | Monoclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IP. |
| PAU905Bo01 | Polyclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU905Bo01 | CLIA Kit for Melanoma Antigen Family A1 (MAGEA1) | CLIA assay for Antigen Detection |
| ELU905Bo01 | ELISA Kit for Melanoma Antigen Family A1 (MAGEA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU905Rb01 | Recombinant Melanoma Antigen Family A1 (MAGEA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU905Rb01 | Monoclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IP. |
| PAU905Rb01 | Polyclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU905Rb01 | CLIA Kit for Melanoma Antigen Family A1 (MAGEA1) | CLIA assay for Antigen Detection |
| ELU905Rb01 | ELISA Kit for Melanoma Antigen Family A1 (MAGEA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU905Mo01 | Recombinant Melanoma Antigen Family A1 (MAGEA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU905Mo01 | Monoclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IP. |
| PAU905Mo01 | Polyclonal Antibody to Melanoma Antigen Family A1 (MAGEA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU905Mo01 | CLIA Kit for Melanoma Antigen Family A1 (MAGEA1) | CLIA assay for Antigen Detection |
| ELU905Mo01 | ELISA Kit for Melanoma Antigen Family A1 (MAGEA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma."
Science 254:1643-1647(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning and analysis of MAGE-1-related genes."
Biochem. Biophys. Res. Commun. 202:549-555(1994) [PubMed] [Europe PMC] [Abstract]
"The genetic polymorphism of melanoma-associated antigen 1 in Chinese normal donors and hepatoma patients."
Zhonghua Gan Zang Bing Za Zhi 12:151-155(2004) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Comparative genome sequence analysis of the Bpa/Str region in mouse and man."
Genome Res. 10:758-775(2000) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes."
J. Exp. Med. 179:921-930(1994) [PubMed] [Europe PMC] [Abstract]
"MAGE-1 gene product is a cytoplasmic protein."
Int. J. Cancer 59:435-439(1994) [PubMed] [Europe PMC] [Abstract]
"MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription."
Nucleic Acids Res. 32:4340-4350(2004) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3."
J. Biol. Chem. 280:2972-2980(2005) [PubMed] [Europe PMC] [Abstract]
"Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity."
Protein Sci. 18:37-49(2009) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]