Tissue Factor Pathway Inhibitor 2 (TFPI2)

PP5; Placental protein 5

SPN	U901
HGNC	11761
MGI	108543
PubMed	21036731
RGD	628629
UniProt	P48307
Wiki	TFPI2

TFPI is an important regulator of the extrinsic pathway of blood coagulation through its ability to inhibit factor Xa and factor VIIa-tissue factor activity. Sprecher et al. described the molecular cloning and expression of a full-length cDNA that encodes a molecule, designated TFPI2, that has a similar overall domain organization and considerable primary amino acid sequence homology to TFPI. After a 22-residue signal peptide, the mature TFPI2 protein contains 213 amino acids with 18 cysteines and 2 canonical N-linked glycosylation sites. The deduced sequence of mature TFPI2 revealed a short acidic N-terminal region, 3 tandem Kunitz-type domains, and a C-terminal tail highly enriched in basic amino acids. Northern analysis demonstrated that the TFPI2 gene is transcribed in umbilical vein endothelial cells, liver, and placenta.

Reference

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Erratum
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