Immunoglobulin D (IgD)
IGHD; Constant Region Of Heavy Chain Of Immunoglobulin Delta
Immunoglobulin D (IgD) is an antibody isotype that makes up about 1% of proteins in the plasma membranes of immature B-lymphocytes where it is usually coexpressed with another cell surface antibody called IgM. IgD is also produced in a secreted form that is found in very small amounts in blood serum. Secreted IgD is produced as a monomeric antibody with two heavy chains of the delta (delta) class, and two Ig light chains. IgD's function has always been a puzzle in immunology since its discovery in 1964. IgD was recently found to be present in species from cartilaginous fish to human (probably with the exception of birds) Reference. This nearly ubiquitous appearance in species with an adaptive immune system demonstrates that IgD is as ancient as IgM and suggests the notion that IgD has important immunological functions.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U900Hu01 | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NPU900Hu01 | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | MU900Hu22 | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| PU900Hu01 | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU900Hu | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Immunoglobulin D (IgD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Immunoglobulin D (IgD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Immunoglobulin D (IgD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Immunoglobulin D (IgD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Immunoglobulin D (IgD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Immunoglobulin D (IgD) | CLIA assay for Antigen Detection |
Reference
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Science 228:733-737(1985) [PubMed] [Europe PMC] [Abstract]
"The human immunoglobulin C mu-C delta locus: complete nucleotide sequence and structural analysis."
Int. Immunol. 1:296-309(1989) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD."
Proc. Natl. Acad. Sci. U.S.A. 78:6168-6172(1981) [PubMed] [Europe PMC] [Abstract]
"Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function."
Proc. Natl. Acad. Sci. U.S.A. 78:504-508(1981) [PubMed] [Europe PMC] [Abstract]
"Amino acid sequence of galactosamine-containing glycopeptides in the hinge region of a human immunoglobulin D."
Biochem. Biophys. Res. Commun. 105:1066-1071(1982) [PubMed] [Europe PMC] [Abstract]
"Complete amino acid sequence of the Fc region of a human delta chain."
Proc. Natl. Acad. Sci. U.S.A. 78:785-789(1981) [PubMed] [Europe PMC] [Abstract]
"Immunoglobulin D enhances the release of tumor necrosis factor-alpha, and interleukin-1 beta as well as interleukin-1 receptor antagonist from human mononuclear cells."
Immunology 88:355-362(1996) [PubMed] [Europe PMC] [Abstract]
"Immunoglobulin D: properties, measurement, and clinical relevance."
Clin. Diagn. Lab. Immunol. 7:131-140(2000) [PubMed] [Europe PMC] [Abstract]
"Structural and functional properties of membrane and secreted IgD."
Mol. Immunol. 37:871-887(2000) [PubMed] [Europe PMC] [Abstract]
"The riddle of the dual expression of IgM and IgD."
Immunology 118:429-437(2006) [PubMed] [Europe PMC] [Abstract]
"Amino acid sequence and location of the three glycopeptides in the Fc region of human immunoglobulin D."
Biochem. Biophys. Res. Commun. 97:635-641(1980) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]