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Neurofibromin 2 (NF2)

ACN; BANF; SCH; Merlin; Bilateral Acoustic Neuroma; Schwannomin; Schwannomerlin; Moesin-Ezrin-Radixin-Like Protein

Merlin is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in Neurofibromatosis type II.Sequence data reveal its similarity to the ERM protein family.The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein". Human merlin is coded by the gene NF2 in Chromosome 22. Mouse merlin gene is located on the chromosome 11 and rat merlin gene on the chromosome 17. Fruit fly merlin gene (symbol Mer) is located on chromosome 1 and shares 58% similarity to its human homologue. Other merlin-like genes are known from a wide range of animals, and the derivation of merlin is thought to be in early metazoa. Merlin is a member of the ERM family of proteins including ezrin, moesin, and radixin, which are in the protein 4.1 superfamily of proteins.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU896Hu01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU896Hu01 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
PAU896Hu01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IF.
Assay Kits CLU896Hu01 CLIA Kit for Neurofibromin 2 (NF2) CLIA assay for Antigen Detection
ELU896Hu01 ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU896Mu01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU896Mu01 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
PAU896Mu01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IF.
Assay Kits CLU896Mu01 CLIA Kit for Neurofibromin 2 (NF2) CLIA assay for Antigen Detection
ELU896Mu01 ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU896Ra01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU896Ra01 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
PAU896Ra01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IF.
Assay Kits CLU896Ra01 CLIA Kit for Neurofibromin 2 (NF2) CLIA assay for Antigen Detection
ELU896Ra01 ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU896Ca01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU896Ca01 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
PAU896Ca01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IF.
Assay Kits CLU896Ca01 CLIA Kit for Neurofibromin 2 (NF2) CLIA assay for Antigen Detection
ELU896Ca01 ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU896Po01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU896Po01 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
PAU896Po01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IF.
Assay Kits CLU896Po01 CLIA Kit for Neurofibromin 2 (NF2) CLIA assay for Antigen Detection
ELU896Po01 ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU896Bo01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU896Bo01 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
PAU896Bo01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IF.
Assay Kits CLU896Bo01 CLIA Kit for Neurofibromin 2 (NF2) CLIA assay for Antigen Detection
ELU896Bo01 ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU896Rb01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU896Rb01 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
PAU896Rb01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IF.
Assay Kits CLU896Rb01 CLIA Kit for Neurofibromin 2 (NF2) CLIA assay for Antigen Detection
ELU896Rb01 ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU896Mo01 Recombinant Neurofibromin 2 (NF2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU896Mo01 Monoclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IP.
PAU896Mo01 Polyclonal Antibody to Neurofibromin 2 (NF2) WB; IHC; ICC; IF.
Assay Kits CLU896Mo01 CLIA Kit for Neurofibromin 2 (NF2) CLIA assay for Antigen Detection
ELU896Mo01 ELISA Kit for Neurofibromin 2 (NF2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2."
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"NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins."
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"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation."
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"Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin."
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"Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus."
Cell 140:477-490(2010) [PubMed] [Europe PMC] [Abstract]

"Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded."
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"Kibra Is a regulator of the Salvador/Warts/Hippo signaling network."
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"Exon scanning for mutation of the NF2 gene in schwannomas."
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"A missense mutation in the NF2 gene results in moderate and mild clinical phenotypes of neurofibromatosis type 2."
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Erratum
J. Med. Genet. 36:87-87(1999)

"Germ-line NF2 mutations and disease severity in neurofibromatosis type 2 patients with retinal abnormalities."
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"Detection of novel NF2 mutations by an RNA mismatch cleavage method."
Hum. Mutat. 15:474-478(2000) [PubMed] [Europe PMC] [Abstract]

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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Evidence of a four-hit mechanism involving SMARCB1 and NF2 in schwannomatosis-associated schwannomas."
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"Molecular characterization of the NF2 gene in Korean patients with neurofibromatosis type 2: a report of four novel mutations."
Korean J. Lab. Med. 30:190-194(2010) [PubMed] [Europe PMC] [Abstract]