Sperm Protein 17 (Sp17)

SPA17; SP17; SP17-1; CT22; Sperm Autoantigenic Protein 17; Cancer/Testis Antigen 22

SPN	U894
HGNC	11210
MGI	1333778
PubMed	18779750
RGD	620154
UniProt	Q15506
Wiki	SPA17

Sperm surface protein Sp17 is a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion.

The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.
 

Reference

"Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17."
Biochim. Biophys. Acta 1307:263-266(1996) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model."
Biochim. Biophys. Acta 1578:29-42(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies."
Int. J. Cancer 121:1507-1511(2007) [PubMed] [Europe PMC] [Abstract]