Tar DNA Binding Protein 43kDa (TDP43)
TARDBP; ALS10
TAR DNA-binding protein is a cellular factor of 43 kDa that binds specifically to pyrimidine-rich motifs in TAR. Antibody to TDP-43 was used in gel retardation assays to demonstrate that endogenous TDP-43, present in HeLa nuclear extract, also bound to TAR DNA.
Although TDP-43 bound strongly to double-stranded TAR DNA via its ribonucleoprotein protein- binding motifs, it did not bind to TAR RNA extending from 1 to 80. TDP-43 is capable of modulating both in vitro and in vivo HIV-1 gene expression by either altering or blocking the assembly of transcription complexes that are capable of responding to Tat.TDP-43 is the major disease protein in both disorders.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU891Hu01 | Recombinant Tar DNA Binding Protein 43kDa (TDP43) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU891Hu01 | Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IP. |
| PAU891Hu01 | Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU891Hu01 | CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) | CLIA assay for Antigen Detection |
| ELU891Hu01 | ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU891Mu01 | Recombinant Tar DNA Binding Protein 43kDa (TDP43) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU891Mu01 | Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IP. |
| PAU891Mu01 | Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU891Mu01 | CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) | CLIA assay for Antigen Detection |
| ELU891Mu01 | ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU891Ra01 | Recombinant Tar DNA Binding Protein 43kDa (TDP43) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU891Ra01 | Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IP. |
| PAU891Ra01 | Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU891Ra01 | CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) | CLIA assay for Antigen Detection |
| ELU891Ra01 | ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU891Ca01 | Recombinant Tar DNA Binding Protein 43kDa (TDP43) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU891Ca01 | Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IP. |
| PAU891Ca01 | Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU891Ca01 | CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) | CLIA assay for Antigen Detection |
| ELU891Ca01 | ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU891Po01 | Recombinant Tar DNA Binding Protein 43kDa (TDP43) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU891Po01 | Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IP. |
| PAU891Po01 | Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU891Po01 | CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) | CLIA assay for Antigen Detection |
| ELU891Po01 | ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU891Bo01 | Recombinant Tar DNA Binding Protein 43kDa (TDP43) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU891Bo01 | Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IP. |
| PAU891Bo01 | Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU891Bo01 | CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) | CLIA assay for Antigen Detection |
| ELU891Bo01 | ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU891Rb01 | Recombinant Tar DNA Binding Protein 43kDa (TDP43) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU891Rb01 | Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IP. |
| PAU891Rb01 | Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU891Rb01 | CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) | CLIA assay for Antigen Detection |
| ELU891Rb01 | ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU891Mo01 | Recombinant Tar DNA Binding Protein 43kDa (TDP43) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU891Mo01 | Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IP. |
| PAU891Mo01 | Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU891Mo01 | CLIA Kit for Tar DNA Binding Protein 43kDa (TDP43) | CLIA assay for Antigen Detection |
| ELU891Mo01 | ELISA Kit for Tar DNA Binding Protein 43kDa (TDP43) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs."
J. Virol. 69:3584-3596(1995) [PubMed] [Europe PMC] [Abstract]
"TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein."
Mol. Cell. Neurosci. 35:320-327(2007) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
, Submitted (MAR-2007) to UniProtKB
"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis."
Science 314:130-133(2006) [PubMed] [Europe PMC] [Abstract]
"Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping."
EMBO J. 20:1774-1784(2001) [PubMed] [Europe PMC] [Abstract]
"Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9."
J. Biol. Chem. 276:36337-36343(2001) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS."
Nature 466:1069-1075(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Mutations in the matrin 3 gene cause familial amyotrophic lateral sclerosis."
Nat. Neurosci. 17:664-666(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the RNA binding domains of TAR DNA-binding protein-43."
Submitted (NOV-2005) to the PDB data bank
"Solution structure of RRM domain in tar DNA-binding protein-43."
Submitted (FEB-2009) to the PDB data bank
"TDP-43 A315T mutation in familial motor neuron disease."
Ann. Neurol. 63:535-538(2008) [PubMed] [Europe PMC] [Abstract]
"TDP-43 mutation in familial amyotrophic lateral sclerosis."
Ann. Neurol. 63:538-542(2008) [PubMed] [Europe PMC] [Abstract]
"TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis."
Lancet Neurol. 7:409-416(2008) [PubMed] [Europe PMC] [Abstract]
"TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis."
Nat. Genet. 40:572-574(2008) [PubMed] [Europe PMC] [Abstract]
"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis."
Science 319:1668-1672(2008) [PubMed] [Europe PMC] [Abstract]
"TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration."
Ann. Neurol. 65:470-473(2009) [PubMed] [Europe PMC] [Abstract]
"High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis."
Hum. Mutat. 30:688-694(2009) [PubMed] [Europe PMC] [Abstract]
"Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease."
Hum. Mutat. 30:E974-E983(2009) [PubMed] [Europe PMC] [Abstract]
"Genetic variants in the promoter of TARDBP in sporadic amyotrophic lateral sclerosis."
Neuromuscul. Disord. 19:696-700(2009) [PubMed] [Europe PMC] [Abstract]
"Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene."
Arch. Neurol. 68:594-598(2011) [PubMed] [Europe PMC] [Abstract]
"High frequency of the TARDBP p.Ala382Thr mutation in Sardinian patients with amyotrophic lateral sclerosis."
Clin. Genet. 81:172-178(2012) [PubMed] [Europe PMC] [Abstract]
"Novel TARDBP mutations in Nordic ALS patients."
J. Hum. Genet. 57:316-319(2012) [PubMed] [Europe PMC] [Abstract]