Glutathione S Transferase Alpha 2 (GSTa2)

GST-A2; GST2; GSTA2-2; GTA2; GTH2

SPN	U885
HGNC	4627
MGI	95863
PubMed	19639209
RGD	2754
UniProt	P09210
Wiki	GSTA2

These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. Glutathione S-transferase A2 is a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Reference

"The basic glutathione S-transferases from human livers are products of separate genes."
Biochem. Biophys. Res. Commun. 145:474-481(1987) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the human glutathione S-transferase A2 subunit gene."
Arch. Biochem. Biophys. 298:747-752(1992) [PubMed] [Europe PMC] [Abstract]

"Cloning, sequencing and characterization of the human alpha glutathione S-transferase gene corresponding to the cDNA clone pGTH2."
Biochem. J. 285:925-928(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver."
Biochim. Biophys. Acta 1161:333-336(1993) [PubMed] [Europe PMC] [Abstract]

"Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other alpha class glutathione S-transferases."
Biochem. J. 264:437-445(1989) [PubMed] [Europe PMC] [Abstract]

"A surface mutant (G82R) of a human alpha-glutathione S-transferase shows decreased thermal stability and a new mode of molecular association in the crystal."
Proteins 20:259-263(1994) [PubMed] [Europe PMC] [Abstract]

"Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases."
J. Mol. Biol. 397:332-340(2010) [PubMed] [Europe PMC] [Abstract]

"Polymorphism of human alpha class glutathione transferases."
Pharmacogenetics 11:609-617(2001) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]