Arachidonate-12-Lipoxygenase (ALOX12)
LOX12; 12-LOX; ALOX-12; 12-LO; 12LPG; LOG12; Lipoxygenase 12; 12S-lipoxygenase; Lipoxin synthase 12-LO; Platelet-type lipoxygenase 12
Arachidonate 12-lipoxygenase introduces a molecular oxygen into the C-12 position of arachidonic acid to produce 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid. The major pathway of arachidonic acid metabolism in human platelets proceeds via a 12-lipoxygenase enzyme. Expression of the LOG12 gene was detected in human erythroleukemia cells, platelets, and human umbilical vein endothelial cells by reverse transcription-PCR analysis. The presumed pseudogene showed no detectable expression in several tissues and cell lines. Arachidonate 12-lipoxygenase introduces a molecular oxygen into C-12 of arachidonic acid. The enzyme is present also in leukocytes and has been found in various mammalian tissues such as porcine and bovine leukocytes, murine eosinophils, bovine tracheal cells, and porcine pituitary cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU877Hu01 | Recombinant Arachidonate-12-Lipoxygenase (ALOX12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU877Hu01 | Monoclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IP. |
| PAU877Hu01 | Polyclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU877Hu01 | CLIA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | CLIA assay for Antigen Detection |
| ELU877Hu01 | ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU877Mu01 | Recombinant Arachidonate-12-Lipoxygenase (ALOX12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU877Mu01 | Monoclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IP. |
| PAU877Mu01 | Polyclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU877Mu01 | CLIA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | CLIA assay for Antigen Detection |
| ELU877Mu01 | ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU877Ra01 | Recombinant Arachidonate-12-Lipoxygenase (ALOX12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU877Ra01 | Monoclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IP. |
| PAU877Ra01 | Polyclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU877Ra01 | CLIA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | CLIA assay for Antigen Detection |
| ELU877Ra01 | ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU877Ca01 | Recombinant Arachidonate-12-Lipoxygenase (ALOX12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU877Ca01 | Monoclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IP. |
| PAU877Ca01 | Polyclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU877Ca01 | CLIA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | CLIA assay for Antigen Detection |
| ELU877Ca01 | ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU877Po01 | Recombinant Arachidonate-12-Lipoxygenase (ALOX12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU877Po01 | Monoclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IP. |
| PAU877Po01 | Polyclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU877Po01 | CLIA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | CLIA assay for Antigen Detection |
| ELU877Po01 | ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU877Bo01 | Recombinant Arachidonate-12-Lipoxygenase (ALOX12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU877Bo01 | Monoclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IP. |
| PAU877Bo01 | Polyclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU877Bo01 | CLIA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | CLIA assay for Antigen Detection |
| ELU877Bo01 | ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU877Rb01 | Recombinant Arachidonate-12-Lipoxygenase (ALOX12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU877Rb01 | Monoclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IP. |
| PAU877Rb01 | Polyclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU877Rb01 | CLIA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | CLIA assay for Antigen Detection |
| ELU877Rb01 | ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU877Mo01 | Recombinant Arachidonate-12-Lipoxygenase (ALOX12) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU877Mo01 | Monoclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IP. |
| PAU877Mo01 | Polyclonal Antibody to Arachidonate-12-Lipoxygenase (ALOX12) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU877Mo01 | CLIA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | CLIA assay for Antigen Detection |
| ELU877Mo01 | ELISA Kit for Arachidonate-12-Lipoxygenase (ALOX12) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Exp. Cell Res. 319:1586-1593(2013) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12s-type."
Submitted (FEB-2009) to the PDB data bank
"Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."
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