Syndecan 1 (SDC1)

CD138; SDC; SYND1; Syndecan Proteoglycan 1

SPN	U876
HGNC	10658
MGI	1349162
PubMed	10478144
RGD	3648
UniProt	P18827
Wiki	CD138

Syndecan 1 is  a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

Reference

"Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts."
J. Biol. Chem. 267:1116-1122(1992) [PubMed] [Europe PMC] [Abstract]

"Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans."
J. Biol. Chem. 265:6884-6889(1990) [PubMed] [Europe PMC] [Abstract]

"Shift of syndecan-1 expression from epithelial to stromal cells during progression of solid tumours."
Eur. J. Cancer 40:1373-1382(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p."
Hum. Genet. 99:295-297(1997) [PubMed] [Europe PMC] [Abstract]

"Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation."
J. Biol. Chem. 272:14713-14720(1997) [PubMed] [Europe PMC] [Abstract]

"Adhesion signaling by a novel mitotic substrate of src kinases."
Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics."
Structure 21:342-354(2013) [PubMed] [Europe PMC] [Abstract]