Apolipoprotein A4 (APOA4)
ApoA-IV; ApoAIV; Apo-A4
APOA4 resides on chromosome 11 in close linkage to APOA1 and APOC3. APOA4 contains 3 exons separated by two introns, and is polymorphic, although most of the reported sequence polymorphisms occur in exon 3. The best validated and studied non-synonymous SNPs are a glutamine => histidine substitution at codon 380 and a threonine => serine substitution at codon 367; a sequence polymorphism has also been identified in the 3'UTR of the third exon. Intra-species comparative gene sequence analysis suggests that the APOA4 gene arose from APOA1 by gene duplication approximately 270 MYA.The primary translation product of the APOA4 gene is a 396-residue preprotein, which undergoes proteolytic processing to yield apo A-IV, a 376-reside mature O-linked glycoprotein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU875Hu01 | Recombinant Apolipoprotein A4 (APOA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU875Hu01 | Monoclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IP. |
| PAU875Hu01 | Polyclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU875Hu01 | CLIA Kit for Apolipoprotein A4 (APOA4) | CLIA assay for Antigen Detection |
| ELU875Hu01 | ELISA Kit for Apolipoprotein A4 (APOA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU875Mu01 | Recombinant Apolipoprotein A4 (APOA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU875Mu01 | Monoclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IP. |
| PAU875Mu01 | Polyclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU875Mu01 | CLIA Kit for Apolipoprotein A4 (APOA4) | CLIA assay for Antigen Detection |
| ELU875Mu01 | ELISA Kit for Apolipoprotein A4 (APOA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU875Ra01 | Recombinant Apolipoprotein A4 (APOA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU875Ra01 | Monoclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IP. |
| PAU875Ra01 | Polyclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU875Ra01 | CLIA Kit for Apolipoprotein A4 (APOA4) | CLIA assay for Antigen Detection |
| ELU875Ra01 | ELISA Kit for Apolipoprotein A4 (APOA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU875Ca01 | Recombinant Apolipoprotein A4 (APOA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU875Ca01 | Monoclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IP. |
| PAU875Ca01 | Polyclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU875Ca01 | CLIA Kit for Apolipoprotein A4 (APOA4) | CLIA assay for Antigen Detection |
| ELU875Ca01 | ELISA Kit for Apolipoprotein A4 (APOA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU875Po01 | Recombinant Apolipoprotein A4 (APOA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU875Po01 | Monoclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IP. |
| PAU875Po01 | Polyclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU875Po01 | CLIA Kit for Apolipoprotein A4 (APOA4) | CLIA assay for Antigen Detection |
| ELU875Po01 | ELISA Kit for Apolipoprotein A4 (APOA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU875Bo01 | Recombinant Apolipoprotein A4 (APOA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU875Bo01 | Monoclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IP. |
| PAU875Bo01 | Polyclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU875Bo01 | CLIA Kit for Apolipoprotein A4 (APOA4) | CLIA assay for Antigen Detection |
| ELU875Bo01 | ELISA Kit for Apolipoprotein A4 (APOA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU875Rb01 | Recombinant Apolipoprotein A4 (APOA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU875Rb01 | Monoclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IP. |
| PAU875Rb01 | Polyclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU875Rb01 | CLIA Kit for Apolipoprotein A4 (APOA4) | CLIA assay for Antigen Detection |
| ELU875Rb01 | ELISA Kit for Apolipoprotein A4 (APOA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU875Mo01 | Recombinant Apolipoprotein A4 (APOA4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU875Mo01 | Monoclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IP. |
| PAU875Mo01 | Polyclonal Antibody to Apolipoprotein A4 (APOA4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU875Mo01 | CLIA Kit for Apolipoprotein A4 (APOA4) | CLIA assay for Antigen Detection |
| ELU875Mo01 | ELISA Kit for Apolipoprotein A4 (APOA4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Biochemistry 25:3962-3970(1986) [PubMed] [Europe PMC] [Abstract]
"Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4)."
Proc. Natl. Acad. Sci. U.S.A. 83:8457-8461(1986) [PubMed] [Europe PMC] [Abstract]
"Structure and expression of the human apolipoprotein A-IV gene."
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Hum. Genet. 115:36-56(2004) [PubMed] [Europe PMC] [Abstract]
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Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III."
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Curr. Opin. Lipidol. 2:90-95(1991)
"Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene."
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BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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Structure 20:767-779(2012) [PubMed] [Europe PMC] [Abstract]
"The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360."
Arterioscler. Thromb. 11:851-856(1991) [PubMed] [Europe PMC] [Abstract]
"Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys)."
J. Biol. Chem. 266:13513-13518(1991) [PubMed] [Europe PMC] [Abstract]
Erratum
J. Biol. Chem. 266:19866-19866(1991)
"Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population."
Am. J. Hum. Genet. 50:1115-1128(1992) [PubMed] [Europe PMC] [Abstract]
"A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127."
Biochim. Biophys. Acta 1138:27-33(1992) [PubMed] [Europe PMC] [Abstract]
"Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism."
Genet. Epidemiol. 9:379-388(1992) [PubMed] [Europe PMC] [Abstract]
"Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants."
Hum. Mutat. 5:58-65(1995) [PubMed] [Europe PMC] [Abstract]
"Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity."
Hum. Mutat. 8:319-325(1996) [PubMed] [Europe PMC] [Abstract]
"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]