Tenascin C (TNC)

TN-C; HXB; TN; GMEM; JI; Myotendinous antigen; Neuronectin; GP 150-225; Cytotactin; Hexabrachion; Glioma-associated-extracellular matrix antigen

SPN	U867
HGNC	5318
MGI	101922
PubMed	21281808
RGD	621057
UniProt	P24821
Wiki	Tenascin_C

Tenascin is an extracellular matrix protein with a spatially and temporally restricted tissue distribution. It is a hexomeric, multidomain protein with disulfide-linked subunits of 190 to 240 kD, originally characterized as 'myotendinous antigen.' In the embryo it is present in dense mesenchyme surrounding developing epithelia, in tendon anlagen, and in developing cartilage and bone. In the adult tenascin remains present in tendons and myotendinous junctions in the perichondrium and periosteum, as well as in smooth muscle. Pearson et al. (1988) isolated cDNA clones coding for tenascin from a chicken fibroblast cDNA expression library using a specific tenascin antiserum. They showed induction of tenascin in vitro by fetal calf serum as well as by transforming growth factor-beta .

Reference

"The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats."
J. Biol. Chem. 266:2818-2823(1991) [PubMed] [Europe PMC] [Abstract]

"Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies."
Nucleic Acids Res. 19:525-531(1991) [PubMed] [Europe PMC] [Abstract]

"Structure of the human hexabrachion (tenascin) gene."
Proc. Natl. Acad. Sci. U.S.A. 88:9438-9442(1991) [PubMed] [Europe PMC] [Abstract]

"Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences."
J. Biol. Chem. 270:3429-3434(1995) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes."
Biochim. Biophys. Acta 1219:613-622(1994) [PubMed] [Europe PMC] [Abstract]

"An alternatively spliced region of the human hexabrachion contains a repeat of potential N-glycosylation sites."
Proc. Natl. Acad. Sci. U.S.A. 86:1588-1592(1989) [PubMed] [Europe PMC] [Abstract]

"Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules."
J. Biol. Chem. 271:26110-26116(1996) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein."
Science 258:987-991(1992) [PubMed] [Europe PMC] [Abstract]

"Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss."
PLoS ONE 8:E69549-E69549(2013) [PubMed] [Europe PMC] [Abstract]