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Complement Factor I (CFI)

CF-I; C3b-INA; FI; IF; KAF; Factor I; Konglutinogen-Activating Factor; C3b-Inactivator; C3B/C4B inactivator

Factor I is a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U865Hu01 Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies MU865Hu22 Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
PU865Hu01 Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits KEU865Hu ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U865Mu01 Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
PU865Mu01 Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Complement Factor I (CFI) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Complement Factor I (CFI) Bioactivity
Antibodies NONE Monoclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Complement Factor I (CFI) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Complement Factor I (CFI) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Complement Factor I (CFI) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Complement Factor I (CFI) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Complement Factor I (CFI) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Complement Factor I (CFI) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Complement Factor I (CFI) CLIA assay for Antigen Detection

Reference

"Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones."
Biochem. J. 242:849-856(1987) [PubMed] [Europe PMC] [Abstract]

"Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4."
J. Biol. Chem. 262:10065-10071(1987) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of the promoter for the human complement factor I (C3b/C4b inactivator) gene."
Gene 208:17-24(1998) [PubMed] [Europe PMC] [Abstract]

"Beta-sheet secondary structure of an LDL receptor domain from complement factor I by consensus structure predictions and spectroscopy."
FEBS Lett. 371:199-203(1995) [PubMed] [Europe PMC] [Abstract]

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis for complement factor I control and its disease-associated sequence polymorphisms."
Proc. Natl. Acad. Sci. U.S.A. 108:12839-12844(2011) [PubMed] [Europe PMC] [Abstract]

"The molecular basis of hereditary complement factor I deficiency."
J. Clin. Invest. 97:925-933(1996) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of homozygous hereditary factor I deficiency."
Clin. Exp. Immunol. 131:280-286(2003) [PubMed] [Europe PMC] [Abstract]

"Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome."
J. Med. Genet. 41:E84-E84(2004) [PubMed] [Europe PMC] [Abstract]

"Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome."
Blood 108:1267-1279(2006) [PubMed] [Europe PMC] [Abstract]

"Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome."
J. Med. Genet. 44:193-199(2007) [PubMed] [Europe PMC] [Abstract]

"A missense mutation in factor I (IF) predisposes to atypical haemolytic uraemic syndrome."
Pediatr. Nephrol. 22:371-375(2007) [PubMed] [Europe PMC] [Abstract]

"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Hum. Mutat. 31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]

"A functional variant in the CFI gene confers a high risk of age-related macular degeneration."
Nat. Genet. 45:813-817(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]