Interleukin 33 (IL33)
DV27; C9ORF26; IL1F11; NFHEV; Interleukin-1 Family, Member 11; Nuclear factor from high endothelial venules
Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. This cytokine was previously named NF-HEV 'nuclear factor (NF) in high endothelial venules' (HEVs) since it was originally identified in these specialized cells. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U863Hu01 | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | MU863Hu22 | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| PU863Hu01 | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| LU863Hu71 | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU863Hu | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCU863Hu | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U863Mu01 | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| PU863Mu01 | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| LU863Mu71 | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| LU863Mu81 | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU863Mu | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCU863Mu | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U863Ra01 | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | MU863Ra21 | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| PU863Ra01 | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU863Ra | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| KCU863Ra | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Interleukin 33 (IL33) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Interleukin 33 (IL33) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Interleukin 33 (IL33) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Interleukin 33 (IL33) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Interleukin 33 (IL33) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Interleukin 33 (IL33) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Interleukin 33 (IL33) | CLIA assay for Antigen Detection |
Reference
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Am. J. Pathol. 163:69-79(2003) [PubMed] [Europe PMC] [Abstract]
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Immunity 23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 109:1673-1678(2012) [PubMed] [Europe PMC] [Abstract]
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Eur. J. Immunol. 37:2779-2786(2007) [PubMed] [Europe PMC] [Abstract]
"IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo."
Proc. Natl. Acad. Sci. U.S.A. 104:282-287(2007) [PubMed] [Europe PMC] [Abstract]
"Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation."
Am. J. Pathol. 173:1229-1242(2008) [PubMed] [Europe PMC] [Abstract]
"The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?"
PLoS ONE 3:E3331-E3331(2008) [PubMed] [Europe PMC] [Abstract]
"Mature interleukin-33 is produced by calpain-mediated cleavage in vivo."
Biochem. Biophys. Res. Commun. 387:218-222(2009) [PubMed] [Europe PMC] [Abstract]
"Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases."
Immunity 31:84-98(2009) [PubMed] [Europe PMC] [Abstract]
"Interleukin-33 is biologically active independently of caspase-1 cleavage."
J. Biol. Chem. 284:19420-19426(2009) [PubMed] [Europe PMC] [Abstract]
"The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1."
Proc. Natl. Acad. Sci. U.S.A. 106:9021-9026(2009) [PubMed] [Europe PMC] [Abstract]
"The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription."
J. Immunol. 187:1609-1616(2011) [PubMed] [Europe PMC] [Abstract]
"Interleukin 33 as a mechanically responsive cytokine secreted by living cells."
J. Biol. Chem. 287:6941-6948(2012) [PubMed] [Europe PMC] [Abstract]
"Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes."
Structure 17:1398-1410(2009) [PubMed] [Europe PMC] [Abstract]
"Structural insights into the interaction of IL-33 with its receptors."
Proc. Natl. Acad. Sci. U.S.A. 110:14918-14923(2013) [PubMed] [Europe PMC] [Abstract]