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Toll Like Receptor 1 (TLR1)

CD281; TIL; Rsc786; Toll/interleukin-1 receptor-like protein

TLR 1 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU855Hu01 Recombinant Toll Like Receptor 1 (TLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU855Hu01 Monoclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IP.
PAU855Hu01 Polyclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IF.
Assay Kits CLU855Hu01 CLIA Kit for Toll Like Receptor 1 (TLR1) CLIA assay for Antigen Detection
ELU855Hu01 ELISA Kit for Toll Like Receptor 1 (TLR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU855Mu01 Recombinant Toll Like Receptor 1 (TLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU855Mu01 Monoclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IP.
PAU855Mu01 Polyclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IF.
Assay Kits CLU855Mu01 CLIA Kit for Toll Like Receptor 1 (TLR1) CLIA assay for Antigen Detection
ELU855Mu01 ELISA Kit for Toll Like Receptor 1 (TLR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU855Ra01 Recombinant Toll Like Receptor 1 (TLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU855Ra01 Monoclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IP.
PAU855Ra01 Polyclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IF.
Assay Kits CLU855Ra01 CLIA Kit for Toll Like Receptor 1 (TLR1) CLIA assay for Antigen Detection
ELU855Ra01 ELISA Kit for Toll Like Receptor 1 (TLR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU855Ca01 Recombinant Toll Like Receptor 1 (TLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU855Ca01 Monoclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IP.
PAU855Ca01 Polyclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IF.
Assay Kits CLU855Ca01 CLIA Kit for Toll Like Receptor 1 (TLR1) CLIA assay for Antigen Detection
ELU855Ca01 ELISA Kit for Toll Like Receptor 1 (TLR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU855Po01 Recombinant Toll Like Receptor 1 (TLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU855Po01 Monoclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IP.
PAU855Po01 Polyclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IF.
Assay Kits CLU855Po01 CLIA Kit for Toll Like Receptor 1 (TLR1) CLIA assay for Antigen Detection
ELU855Po01 ELISA Kit for Toll Like Receptor 1 (TLR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU855Bo01 Recombinant Toll Like Receptor 1 (TLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU855Bo01 Monoclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IP.
PAU855Bo01 Polyclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IF.
Assay Kits CLU855Bo01 CLIA Kit for Toll Like Receptor 1 (TLR1) CLIA assay for Antigen Detection
ELU855Bo01 ELISA Kit for Toll Like Receptor 1 (TLR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU855Rb01 Recombinant Toll Like Receptor 1 (TLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU855Rb01 Monoclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IP.
PAU855Rb01 Polyclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IF.
Assay Kits CLU855Rb01 CLIA Kit for Toll Like Receptor 1 (TLR1) CLIA assay for Antigen Detection
ELU855Rb01 ELISA Kit for Toll Like Receptor 1 (TLR1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU855Mo01 Recombinant Toll Like Receptor 1 (TLR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU855Mo01 Monoclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IP.
PAU855Mo01 Polyclonal Antibody to Toll Like Receptor 1 (TLR1) WB; IHC; ICC; IF.
Assay Kits CLU855Mo01 CLIA Kit for Toll Like Receptor 1 (TLR1) CLIA assay for Antigen Detection
ELU855Mo01 ELISA Kit for Toll Like Receptor 1 (TLR1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A family of human receptors structurally related to Drosophila Toll."
Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) [PubMed] [Europe PMC] [Abstract]

"Natural selection in the TLR-related genes in the course of primate evolution."
Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy."
J. Immunol. 178:7520-7524(2007) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."
Nature 408:111-115(2000) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide."
Cell 130:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]

"Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions."
J. Infect. Dis. 199:1816-1819(2009) [PubMed] [Europe PMC] [Abstract]

"Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]