Toll Like Receptor 3 (TLR3)
CD283
TLR 3 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. Discovered in 2001,TLR3 recognizes double-stranded RNA, a form of genetic information carried by some viruses such as reoviruses. Upon recognition, TLR 3 induces the activation of NF-kB to increase production of type I interferons which signal other cells to increase their antiviral defenses.
Double-stranded RNA is also recognised by the cytoplasmic receptors RIG-I and MDA-5.The structure of TLR3 was reported in June 2005 by researchers at The Scripps Research Institute. TLR3 forms a large horseshoe shape that contacts with a neighboring horseshoe, forming a "dimer" of two horseshoes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU854Hu01 | Recombinant Toll Like Receptor 3 (TLR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU854Hu01 | Monoclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IP. |
| PAU854Hu01 | Polyclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU854Hu01 | CLIA Kit for Toll Like Receptor 3 (TLR3) | CLIA assay for Antigen Detection |
| ELU854Hu01 | ELISA Kit for Toll Like Receptor 3 (TLR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU854Mu01 | Recombinant Toll Like Receptor 3 (TLR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU854Mu01 | Monoclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IP. |
| PAU854Mu01 | Polyclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU854Mu01 | CLIA Kit for Toll Like Receptor 3 (TLR3) | CLIA assay for Antigen Detection |
| ELU854Mu01 | ELISA Kit for Toll Like Receptor 3 (TLR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU854Ra01 | Recombinant Toll Like Receptor 3 (TLR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU854Ra01 | Monoclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IP. |
| PAU854Ra01 | Polyclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU854Ra01 | CLIA Kit for Toll Like Receptor 3 (TLR3) | CLIA assay for Antigen Detection |
| ELU854Ra01 | ELISA Kit for Toll Like Receptor 3 (TLR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU854Ca01 | Recombinant Toll Like Receptor 3 (TLR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU854Ca01 | Monoclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IP. |
| PAU854Ca01 | Polyclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU854Ca01 | CLIA Kit for Toll Like Receptor 3 (TLR3) | CLIA assay for Antigen Detection |
| ELU854Ca01 | ELISA Kit for Toll Like Receptor 3 (TLR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU854Po01 | Recombinant Toll Like Receptor 3 (TLR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU854Po01 | Monoclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IP. |
| PAU854Po01 | Polyclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU854Po01 | CLIA Kit for Toll Like Receptor 3 (TLR3) | CLIA assay for Antigen Detection |
| ELU854Po01 | ELISA Kit for Toll Like Receptor 3 (TLR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU854Bo01 | Recombinant Toll Like Receptor 3 (TLR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU854Bo01 | Monoclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IP. |
| PAU854Bo01 | Polyclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU854Bo01 | CLIA Kit for Toll Like Receptor 3 (TLR3) | CLIA assay for Antigen Detection |
| ELU854Bo01 | ELISA Kit for Toll Like Receptor 3 (TLR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU854Rb01 | Recombinant Toll Like Receptor 3 (TLR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU854Rb01 | Monoclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IP. |
| PAU854Rb01 | Polyclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU854Rb01 | CLIA Kit for Toll Like Receptor 3 (TLR3) | CLIA assay for Antigen Detection |
| ELU854Rb01 | ELISA Kit for Toll Like Receptor 3 (TLR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU854Mo01 | Recombinant Toll Like Receptor 3 (TLR3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU854Mo01 | Monoclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IP. |
| PAU854Mo01 | Polyclonal Antibody to Toll Like Receptor 3 (TLR3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU854Mo01 | CLIA Kit for Toll Like Receptor 3 (TLR3) | CLIA assay for Antigen Detection |
| ELU854Mo01 | ELISA Kit for Toll Like Receptor 3 (TLR3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
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J. Immunol. 169:6668-6672(2002) [PubMed] [Europe PMC] [Abstract]
"TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction."
Nat. Immunol. 4:161-167(2003) [PubMed] [Europe PMC] [Abstract]
"Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH."
J. Biol. Chem. 280:38133-38145(2005) [PubMed] [Europe PMC] [Abstract]
"Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling."
EMBO J. 25:3335-3346(2006) [PubMed] [Europe PMC] [Abstract]
"The dsRNA binding site of human Toll-like receptor 3."
Proc. Natl. Acad. Sci. U.S.A. 103:8792-8797(2006) [PubMed] [Europe PMC] [Abstract]
"Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation."
J. Biol. Chem. 282:3423-3427(2007) [PubMed] [Europe PMC] [Abstract]
"The TLR3 signaling complex forms by cooperative receptor dimerization."
Proc. Natl. Acad. Sci. U.S.A. 105:258-263(2008) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling."
Proc. Natl. Acad. Sci. U.S.A. 109:9053-9058(2012) [PubMed] [Europe PMC] [Abstract]
"The molecular structure of the Toll-like receptor 3 ligand-binding domain."
Proc. Natl. Acad. Sci. U.S.A. 102:10976-10980(2005) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human toll-like receptor 3 (TLR3) ectodomain."
Science 309:581-585(2005) [PubMed] [Europe PMC] [Abstract]
"Lateral clustering of TLR3:dsRNA signaling units revealed by TLR3ecd:3Fabs quaternary structure."
J. Mol. Biol. 421:112-124(2012) [PubMed] [Europe PMC] [Abstract]
"TLR3 deficiency in patients with herpes simplex encephalitis."
Science 317:1522-1527(2007) [PubMed] [Europe PMC] [Abstract]
"Toll-like receptor 3 and geographic atrophy in age-related macular degeneration."
N. Engl. J. Med. 359:1456-1463(2008) [PubMed] [Europe PMC] [Abstract]
Erratum
N. Engl. J. Med. 359:1859-1859(2008)
"A common polymorphism in TLR3 confers natural resistance to HIV-1 infection."
J. Immunol. 188:818-823(2012) [PubMed] [Europe PMC] [Abstract]