Toll Like Receptor 5 (TLR5)

CD285; SLEB1; TIL3; Toll/Interleukin-1 Receptor-Like Protein 3

SPN	U853
HGNC	11851
MGI	1858171
PubMed	19774646
RGD	631351
UniProt	O60602
Wiki	TLR_5

Toll-like receptor 5 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production.

Reference

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Blood 91:4020-4027(1998) [PubMed] [Europe PMC] [Abstract]

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

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"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
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Nature 410:1099-1103(2001) [PubMed] [Europe PMC] [Abstract]

"A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus."
Proc. Natl. Acad. Sci. U.S.A. 102:10593-10597(2005) [PubMed] [Europe PMC] [Abstract]

"A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellin."
Biochem. Biophys. Res. Commun. 352:936-941(2007) [PubMed] [Europe PMC] [Abstract]

"Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin."
J. Immunol. 178:5735-5743(2007) [PubMed] [Europe PMC] [Abstract]

"Impaired TLR5 functionality is associated with survival in melioidosis."
J. Immunol. 190:3373-3379(2013) [PubMed] [Europe PMC] [Abstract]

"Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin."
J. Struct. Biol. 177:402-409(2012) [PubMed] [Europe PMC] [Abstract]

"A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease."
J. Exp. Med. 198:1563-1572(2003) [PubMed] [Europe PMC] [Abstract]