Arrestin Beta 1 (ARRb1)

ARB1; ARR1; ARR-B1; Arrestin 2

SPN	U850
HGNC	711
MGI	99473
PubMed	12614678
RGD	2156
UniProt	P49407
Wiki	ARRB1

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.

Reference

"Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing."
J. Biol. Chem. 268:9753-9761(1993) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2."
Proc. Natl. Acad. Sci. U.S.A. 95:2985-2990(1998) [PubMed] [Europe PMC] [Abstract]

"Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells."
J. Biol. Chem. 274:6831-6834(1999) [PubMed] [Europe PMC] [Abstract]

"Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes."
Science 283:655-661(1999) [PubMed] [Europe PMC] [Abstract]

"Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors."
J. Biol. Chem. 275:17201-17210(2000) [PubMed] [Europe PMC] [Abstract]

"Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI."
Nat. Immunol. 1:227-233(2000) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway."
J. Biol. Chem. 278:4277-4285(2003) [PubMed] [Europe PMC] [Abstract]

"{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase."
J. Biol. Chem. 280:24412-24419(2005) [PubMed] [Europe PMC] [Abstract]

"Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2."
J. Biol. Chem. 279:7807-7811(2004) [PubMed] [Europe PMC] [Abstract]

"A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription."
Cell 123:833-847(2005) [PubMed] [Europe PMC] [Abstract]

"beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation."
J. Biol. Chem. 280:8041-8050(2005) [PubMed] [Europe PMC] [Abstract]

"G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers."
J. Biol. Chem. 280:37503-37515(2005) [PubMed] [Europe PMC] [Abstract]

"Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking."
Mol. Pharmacol. 67:78-87(2005) [PubMed] [Europe PMC] [Abstract]

"Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor."
Proc. Natl. Acad. Sci. U.S.A. 102:1448-1453(2005) [PubMed] [Europe PMC] [Abstract]

"Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly."
Dev. Cell 10:329-342(2006) [PubMed] [Europe PMC] [Abstract]

"beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor."
J. Biol. Chem. 281:1261-1273(2006) [PubMed] [Europe PMC] [Abstract]

"Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation."
J. Biol. Chem. 281:10856-10864(2006) [PubMed] [Europe PMC] [Abstract]

"Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation."
J. Immunol. 176:7039-7050(2006) [PubMed] [Europe PMC] [Abstract]

"Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling."
Nat. Immunol. 7:139-147(2006) [PubMed] [Europe PMC] [Abstract]

"The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor."
Pigment Cell Res. 19:125-135(2006) [PubMed] [Europe PMC] [Abstract]

"Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex."
J. Cell Sci. 120:1723-1732(2007) [PubMed] [Europe PMC] [Abstract]

"Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle."
FASEB J. 22:2134-2141(2008) [PubMed] [Europe PMC] [Abstract]

"Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms."
J. Neurochem. 106:781-792(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2."
Cell. Signal. 21:1748-1757(2009) [PubMed] [Europe PMC] [Abstract]

"Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling."
EMBO J. 28:2706-2718(2009) [PubMed] [Europe PMC] [Abstract]

"A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex."
FEBS Lett. 583:3310-3316(2009) [PubMed] [Europe PMC] [Abstract]

"An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages."
J. Leukoc. Biol. 86:833-845(2009) [PubMed] [Europe PMC] [Abstract]

"Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2."
Proc. Natl. Acad. Sci. U.S.A. 106:6650-6655(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Ubiquitination of CXCR7 controls receptor trafficking."
PLoS ONE 7:E34192-E34192(2012) [PubMed] [Europe PMC] [Abstract]

"Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]

"Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6."
Sci. Signal. 6:RA30-RA30(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly."
PLoS Biol. 4:E262-E262(2006) [PubMed] [Europe PMC] [Abstract]