Arrestin Beta 2 (ARRb2)
ARB2; ARR2; ARR-B2; Arrestin 3
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,as well as having signalling roles in their own right.Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU849Hu01 | Recombinant Arrestin Beta 2 (ARRb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU849Hu01 | Monoclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IP. |
| PAU849Hu01 | Polyclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU849Hu01 | CLIA Kit for Arrestin Beta 2 (ARRb2) | CLIA assay for Antigen Detection |
| ELU849Hu01 | ELISA Kit for Arrestin Beta 2 (ARRb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU849Mu01 | Recombinant Arrestin Beta 2 (ARRb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU849Mu01 | Monoclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IP. |
| PAU849Mu01 | Polyclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU849Mu01 | CLIA Kit for Arrestin Beta 2 (ARRb2) | CLIA assay for Antigen Detection |
| ELU849Mu01 | ELISA Kit for Arrestin Beta 2 (ARRb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU849Ra01 | Recombinant Arrestin Beta 2 (ARRb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU849Ra01 | Monoclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IP. |
| PAU849Ra01 | Polyclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU849Ra01 | CLIA Kit for Arrestin Beta 2 (ARRb2) | CLIA assay for Antigen Detection |
| ELU849Ra01 | ELISA Kit for Arrestin Beta 2 (ARRb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU849Ca01 | Recombinant Arrestin Beta 2 (ARRb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU849Ca01 | Monoclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IP. |
| PAU849Ca01 | Polyclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU849Ca01 | CLIA Kit for Arrestin Beta 2 (ARRb2) | CLIA assay for Antigen Detection |
| ELU849Ca01 | ELISA Kit for Arrestin Beta 2 (ARRb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU849Po01 | Recombinant Arrestin Beta 2 (ARRb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU849Po01 | Monoclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IP. |
| PAU849Po01 | Polyclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU849Po01 | CLIA Kit for Arrestin Beta 2 (ARRb2) | CLIA assay for Antigen Detection |
| ELU849Po01 | ELISA Kit for Arrestin Beta 2 (ARRb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU849Bo01 | Recombinant Arrestin Beta 2 (ARRb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU849Bo01 | Monoclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IP. |
| PAU849Bo01 | Polyclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU849Bo01 | CLIA Kit for Arrestin Beta 2 (ARRb2) | CLIA assay for Antigen Detection |
| ELU849Bo01 | ELISA Kit for Arrestin Beta 2 (ARRb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU849Rb01 | Recombinant Arrestin Beta 2 (ARRb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU849Rb01 | Monoclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IP. |
| PAU849Rb01 | Polyclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU849Rb01 | CLIA Kit for Arrestin Beta 2 (ARRb2) | CLIA assay for Antigen Detection |
| ELU849Rb01 | ELISA Kit for Arrestin Beta 2 (ARRb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU849Mo01 | Recombinant Arrestin Beta 2 (ARRb2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU849Mo01 | Monoclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IP. |
| PAU849Mo01 | Polyclonal Antibody to Arrestin Beta 2 (ARRb2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU849Mo01 | CLIA Kit for Arrestin Beta 2 (ARRb2) | CLIA assay for Antigen Detection |
| ELU849Mo01 | ELISA Kit for Arrestin Beta 2 (ARRb2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of a member of the arrestin family from a human thyroid cDNA library."
Mol. Cell. Endocrinol. 84:R39-R43(1992) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation."
J. Biol. Chem. 272:27497-27500(1997) [PubMed] [Europe PMC] [Abstract]
"beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4."
J. Biol. Chem. 275:2479-2485(2000) [PubMed] [Europe PMC] [Abstract]
"Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors."
J. Biol. Chem. 275:17201-17210(2000) [PubMed] [Europe PMC] [Abstract]
"Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI."
Nat. Immunol. 1:227-233(2000) [PubMed] [Europe PMC] [Abstract]
"Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*."
J. Biol. Chem. 276:19452-19460(2001) [PubMed] [Europe PMC] [Abstract]
"Regulation of arrestin-3 phosphorylation by casein kinase II."
J. Biol. Chem. 277:16837-16846(2002) [PubMed] [Europe PMC] [Abstract]
"Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2."
J. Biol. Chem. 278:6363-6370(2003) [PubMed] [Europe PMC] [Abstract]
"Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference."
Proc. Natl. Acad. Sci. U.S.A. 100:1740-1744(2003) [PubMed] [Europe PMC] [Abstract]
"Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2."
Proc. Natl. Acad. Sci. U.S.A. 100:10782-10787(2003) [PubMed] [Europe PMC] [Abstract]
"Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling."
Science 301:1394-1397(2003) [PubMed] [Europe PMC] [Abstract]
"Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2."
J. Biol. Chem. 279:7807-7811(2004) [PubMed] [Europe PMC] [Abstract]
"Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7."
J. Biol. Chem. 279:23214-23222(2004) [PubMed] [Europe PMC] [Abstract]
"Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor."
J. Biol. Chem. 279:35518-35525(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways."
Mol. Cell 14:303-317(2004) [PubMed] [Europe PMC] [Abstract]
"Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2."
Science 306:2257-2260(2004) [PubMed] [Europe PMC] [Abstract]
"{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase."
J. Biol. Chem. 280:24412-24419(2005) [PubMed] [Europe PMC] [Abstract]
"Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2."
J. Biol. Chem. 280:25651-25658(2005) [PubMed] [Europe PMC] [Abstract]
"G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers."
J. Biol. Chem. 280:37503-37515(2005) [PubMed] [Europe PMC] [Abstract]
"Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking."
Mol. Pharmacol. 67:78-87(2005) [PubMed] [Europe PMC] [Abstract]
"Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis."
Mol. Pharmacol. 67:1229-1236(2005) [PubMed] [Europe PMC] [Abstract]
"Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor."
Proc. Natl. Acad. Sci. U.S.A. 102:1448-1453(2005) [PubMed] [Europe PMC] [Abstract]
"beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform."
Proc. Natl. Acad. Sci. U.S.A. 102:2790-2795(2005) [PubMed] [Europe PMC] [Abstract]
"Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly."
Dev. Cell 10:329-342(2006) [PubMed] [Europe PMC] [Abstract]
"beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor."
J. Biol. Chem. 281:1261-1273(2006) [PubMed] [Europe PMC] [Abstract]
"A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors."
J. Biol. Chem. 281:2932-2938(2006) [PubMed] [Europe PMC] [Abstract]
"Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation."
J. Biol. Chem. 281:10856-10864(2006) [PubMed] [Europe PMC] [Abstract]
"Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."
J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
"Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling."
Nat. Immunol. 7:139-147(2006) [PubMed] [Europe PMC] [Abstract]
"The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor."
Pigment Cell Res. 19:125-135(2006) [PubMed] [Europe PMC] [Abstract]
"The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells."
J. Biol. Chem. 282:21507-21517(2007) [PubMed] [Europe PMC] [Abstract]
"Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms."
J. Neurochem. 106:781-792(2008) [PubMed] [Europe PMC] [Abstract]
"An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
"The type III transforming growth factor-beta receptor negatively regulates nuclear factor kappa B signaling through its interaction with beta-arrestin2."
Carcinogenesis 30:1281-1287(2009) [PubMed] [Europe PMC] [Abstract]
"Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2."
Cell. Signal. 21:1748-1757(2009) [PubMed] [Europe PMC] [Abstract]
"A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex."
FEBS Lett. 583:3310-3316(2009) [PubMed] [Europe PMC] [Abstract]
"An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages."
J. Leukoc. Biol. 86:833-845(2009) [PubMed] [Europe PMC] [Abstract]
"Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2."
Proc. Natl. Acad. Sci. U.S.A. 106:6650-6655(2009) [PubMed] [Europe PMC] [Abstract]
"Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling."
J. Biol. Chem. 285:7805-7817(2010) [PubMed] [Europe PMC] [Abstract]
"Prolyl hydroxylase 2: a novel regulator of beta2 -adrenoceptor internalization."
J. Cell. Mol. Med. 15:2712-2722(2011) [PubMed] [Europe PMC] [Abstract]
"Carboxy-terminus of CXCR7 regulates receptor localization and function."
Int. J. Biochem. Cell Biol. 44:669-678(2012) [PubMed] [Europe PMC] [Abstract]
"Ubiquitination of CXCR7 controls receptor trafficking."
PLoS ONE 7:E34192-E34192(2012) [PubMed] [Europe PMC] [Abstract]
"Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
J. Biol. Chem. 288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]