Apolipoprotein A5 (APOA5)
Apo-A5; APOA-V; APOAV; RAP3; Regeneration-associated protein 3
Apolipoprotein A-V, It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors.
The is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU846Hu01 | Recombinant Apolipoprotein A5 (APOA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU846Hu01 | Monoclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IP. |
| PAU846Hu01 | Polyclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU846Hu01 | CLIA Kit for Apolipoprotein A5 (APOA5) | CLIA assay for Antigen Detection |
| ELU846Hu01 | ELISA Kit for Apolipoprotein A5 (APOA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU846Mu01 | Recombinant Apolipoprotein A5 (APOA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU846Mu01 | Monoclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IP. |
| PAU846Mu01 | Polyclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU846Mu01 | CLIA Kit for Apolipoprotein A5 (APOA5) | CLIA assay for Antigen Detection |
| ELU846Mu01 | ELISA Kit for Apolipoprotein A5 (APOA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU846Ra01 | Recombinant Apolipoprotein A5 (APOA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU846Ra01 | Monoclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IP. |
| PAU846Ra01 | Polyclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU846Ra01 | CLIA Kit for Apolipoprotein A5 (APOA5) | CLIA assay for Antigen Detection |
| ELU846Ra01 | ELISA Kit for Apolipoprotein A5 (APOA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU846Ca01 | Recombinant Apolipoprotein A5 (APOA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU846Ca01 | Monoclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IP. |
| PAU846Ca01 | Polyclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU846Ca01 | CLIA Kit for Apolipoprotein A5 (APOA5) | CLIA assay for Antigen Detection |
| ELU846Ca01 | ELISA Kit for Apolipoprotein A5 (APOA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU846Po01 | Recombinant Apolipoprotein A5 (APOA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU846Po01 | Monoclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IP. |
| PAU846Po01 | Polyclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU846Po01 | CLIA Kit for Apolipoprotein A5 (APOA5) | CLIA assay for Antigen Detection |
| ELU846Po01 | ELISA Kit for Apolipoprotein A5 (APOA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU846Bo01 | Recombinant Apolipoprotein A5 (APOA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU846Bo01 | Monoclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IP. |
| PAU846Bo01 | Polyclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU846Bo01 | CLIA Kit for Apolipoprotein A5 (APOA5) | CLIA assay for Antigen Detection |
| ELU846Bo01 | ELISA Kit for Apolipoprotein A5 (APOA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU846Rb01 | Recombinant Apolipoprotein A5 (APOA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU846Rb01 | Monoclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IP. |
| PAU846Rb01 | Polyclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU846Rb01 | CLIA Kit for Apolipoprotein A5 (APOA5) | CLIA assay for Antigen Detection |
| ELU846Rb01 | ELISA Kit for Apolipoprotein A5 (APOA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU846Mo01 | Recombinant Apolipoprotein A5 (APOA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU846Mo01 | Monoclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IP. |
| PAU846Mo01 | Polyclonal Antibody to Apolipoprotein A5 (APOA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU846Mo01 | CLIA Kit for Apolipoprotein A5 (APOA5) | CLIA assay for Antigen Detection |
| ELU846Mo01 | ELISA Kit for Apolipoprotein A5 (APOA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Apolipoprotein A-V. A novel apolipoprotein associated with an early phase of liver regeneration."
J. Biol. Chem. 276:44512-44520(2001) [PubMed] [Europe PMC] [Abstract]
"The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster."
Hum. Genet. 115:36-56(2004) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing."
Science 294:169-173(2001) [PubMed] [Europe PMC] [Abstract]
"Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis."
Biochemistry 42:9416-9423(2003) [PubMed] [Europe PMC] [Abstract]
"The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element."
J. Biol. Chem. 278:25468-25480(2003) [PubMed] [Europe PMC] [Abstract]
"Structure and interfacial properties of human apolipoprotein A-V."
J. Biol. Chem. 278:34438-34444(2003) [PubMed] [Europe PMC] [Abstract]
"The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins."
Clin. Chem. 51:351-359(2005) [PubMed] [Europe PMC] [Abstract]
"Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution."
Biochim. Biophys. Acta 1771:1464-1468(2007) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels."
Hum. Mol. Genet. 11:3031-3038(2002) [PubMed] [Europe PMC] [Abstract]
"Ser19Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people."
J. Med. Genet. 40:E105-E105(2003) [PubMed] [Europe PMC] [Abstract]
"A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia."
Hum. Mol. Genet. 12:2533-2539(2003) [PubMed] [Europe PMC] [Abstract]
"Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment."
J. Clin. Invest. 115:2862-2869(2005) [PubMed] [Europe PMC] [Abstract]