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Apolipoprotein B (APOB)

Apo-B; FLDB; Apo B-100; Apo B-48

Apolipoprotein B (APOB) is the primary apolipoprotein of low-density lipoproteins (LDL or "bad cholesterol"), which is responsible for carrying cholesterol to tissues. While it is unclear exactly what functional role APOB plays in LDL, it is the primary apolipoprotein component and is absolutely required for its formation. What is clear is that the APOB on the LDL particle acts as a ligand for LDL receptors in various cells throughout the body.

Through a mechanism that is not fully understood, high levels of APOB can lead to plaques that cause vascular disease (atherosclerosis), leading to heart disease. There is considerable evidence that levels of APOB are a better indicator of heart disease risk than total cholesterol or LDL.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U840Hu01 Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies MU840Hu21 Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
PU840Hu01 Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
LU840Hu71 Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits KEU840Hu ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
KCU840Hu CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U840Mu01 Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
PU840Mu01 Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
LU840Mu71 Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
LU840Mu81 FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits KEU840Mu ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U840Ra01 Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies MU840Ra21 Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
PU840Ra01 Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
LU840Ra71 Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
LU840Ra81 FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits KEU840Ra ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U840Po01 Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies MU840Po21 Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
PU840Po01 Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
LU840Po71 Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
LU840Po81 FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits KEU840Po ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Apolipoprotein B (APOB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Apolipoprotein B (APOB) Bioactivity
Antibodies NONE Monoclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Apolipoprotein B (APOB) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Apolipoprotein B (APOB) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Apolipoprotein B (APOB) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Apolipoprotein B (APOB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Apolipoprotein B (APOB) CLIA assay for Antigen Detection

Reference

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Nucleic Acids Res. 14:7501-7503(1986) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of the human apolipoprotein B gene."
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"Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence."
Proc. Natl. Acad. Sci. U.S.A. 83:8142-8146(1986) [PubMed] [Europe PMC] [Abstract]

"The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms."
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Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"Analysis of cDNA clones encoding the entire B-26 region of human apolipoprotein B."
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"Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B."
Proc. Natl. Acad. Sci. U.S.A. 83:1467-1471(1986) [PubMed] [Europe PMC] [Abstract]

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"Human apolipoprotein B-100: cloning, analysis of liver mRNA, and assignment of the gene to chromosome 2."
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Gene 49:29-51(1986) [PubMed] [Europe PMC] [Abstract]

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Cell 50:831-840(1987) [PubMed] [Europe PMC] [Abstract]

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"Carboxyl terminal analysis of human B-48 protein confirms the novel mechanism proposed for chain termination."
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"Identification of a novel in-frame translational stop codon in human intestine apoB mRNA."
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"Molecular cloning of human LDL apolipoprotein B cDNA. Evidence for more than one gene per haploid genome."
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Science 238:363-366(1987) [PubMed] [Europe PMC] [Abstract]

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Nature 323:734-738(1986) [PubMed] [Europe PMC] [Abstract]

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"Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
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"A novel nontruncating APOB gene mutation, R463W, causes familial hypobetalipoproteinemia."
J. Biol. Chem. 278:13442-13452(2003) [PubMed] [Europe PMC] [Abstract]

"Hypobetalipoproteinemia with an apparently recessive inheritance due to a 'de novo' mutation of apolipoprotein B."
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"Quantitative detection of single amino acid polymorphisms by targeted proteomics."
J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]

"Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels."
Hum. Mutat. 33:448-455(2012) [PubMed] [Europe PMC] [Abstract]