Interleukin 8 Receptor Beta (IL8Rb)

CD182; CDw128b; IL8R-B; IL8-RB; CMKAR2; CXCR2; IL8R2; C-X-C chemokine receptor type 2; GRO/MGSA receptor; High affinity interleukin-8 receptor B

SPN	U837
HGNC	6027
MGI	105303
PubMed	16897191
RGD	2906
UniProt	P25025
Wiki	IL8RB

Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.The protein encoded by this gene is a member of the G-protein coupled receptor family.

This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands CXCL2, CXCL3, and CXCL5.
 

Reference

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Science 253:1280-1283(1991) [PubMed] [Europe PMC] [Abstract]

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"Structure, genomic organization, and expression of the human interleukin-8 receptor B gene."
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"Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor."
J. Biol. Chem. 272:8207-8214(1997) [PubMed] [Europe PMC] [Abstract]