Platelet Activating Factor Acetylhydrolase 2 (PAFAH2)

SD-PLA2; Serine-dependent phospholipase A2; Platelet-activating factor acetylhydrolase 2, cytoplasmic

SPN	U824
HGNC	8579
MGI	2140321
PubMed	23658960
RGD	631399
UniProt	Q99487
Wiki	PAFAH2

Platelet-activating factor acetylhydrolase 2, cytoplasmic is a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes.

Additionally, there is a single-subunit serum isoform of this enzyme.PAFAH2 shares approximately 43% identity with plasma PAFAH, but has virtually no similarity to brain PAFAH1B1. Unlike PAFAH, PAFAH2 contains no secretory signal sequence, confirming its intracellular localization.

Reference

"cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase."
J. Biol. Chem. 271:33032-33038(1996) [PubMed] [Europe PMC] [Abstract]

"Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor."
Biochem. J. 330:1309-1315(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Platelet-activating factor acetylhydrolases."
J. Biol. Chem. 272:17895-17898(1997) [PubMed] [Europe PMC] [Abstract]