Tryptase (TPS)
TPSAB1; Tryptase Alpha/Beta 1; Tryptase Alpha II; Tryptase Beta I; Tryptase-I; Tryptase-II; Tryptase-III
Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells that has recently been used as a marker for mast cell activation. It is involved with allergenic response and is suspected to act as a mitogen for fibroblast lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis.
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU821Hu01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU821Hu01 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAU821Hu01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU821Hu01 | CLIA Kit for Tryptase (TPS) | CLIA assay for Antigen Detection |
| ELU821Hu01 | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU821Mu01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU821Mu01 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAU821Mu01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU821Mu01 | CLIA Kit for Tryptase (TPS) | CLIA assay for Antigen Detection |
| ELU821Mu01 | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU821Ra01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU821Ra01 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAU821Ra01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU821Ra01 | CLIA Kit for Tryptase (TPS) | CLIA assay for Antigen Detection |
| ELU821Ra01 | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU821Ca01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU821Ca01 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAU821Ca01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU821Ca01 | CLIA Kit for Tryptase (TPS) | CLIA assay for Antigen Detection |
| ELU821Ca01 | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU821Po01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU821Po01 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAU821Po01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU821Po01 | CLIA Kit for Tryptase (TPS) | CLIA assay for Antigen Detection |
| ELU821Po01 | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU821Bo01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU821Bo01 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAU821Bo01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU821Bo01 | CLIA Kit for Tryptase (TPS) | CLIA assay for Antigen Detection |
| ELU821Bo01 | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU821Rb01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU821Rb01 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAU821Rb01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU821Rb01 | CLIA Kit for Tryptase (TPS) | CLIA assay for Antigen Detection |
| ELU821Rb01 | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU821Mo01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU821Mo01 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAU821Mo01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU821Mo01 | CLIA Kit for Tryptase (TPS) | CLIA assay for Antigen Detection |
| ELU821Mo01 | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of complementary DNA for human tryptase."
J. Clin. Invest. 84:1188-1195(1989) [PubMed] [Europe PMC] [Abstract]
"Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family."
Proc. Natl. Acad. Sci. U.S.A. 87:3811-3815(1990) [PubMed] [Europe PMC] [Abstract]
"Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3."
J. Biol. Chem. 274:3355-3362(1999) [PubMed] [Europe PMC] [Abstract]
"Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations."
J. Allergy Clin. Immunol. 124:1099-1105(2009) [PubMed] [Europe PMC] [Abstract]
"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates."
J. Biol. Chem. 262:1363-1373(1987) [PubMed] [Europe PMC] [Abstract]
"Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."
Blood 103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]
"Active monomers of human beta-tryptase have expanded substrate specificities."
Int. Immunopharmacol. 7:1900-1908(2007) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region."
J. Mol. Biol. 321:491-502(2002) [PubMed] [Europe PMC] [Abstract]
"Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog."
Pharmacogenetics 10:389-396(2000) [PubMed] [Europe PMC] [Abstract]