Creatine Kinase, Brain (CKB)

CK-BB; CKBB; CK-B; CK-1

SPN	U813
HGNC	1991
MGI	88407
PubMed	7805577
RGD	2357
UniProt	P12277
Wiki	CKB_(gene

Brain-type creatine kinase consists of a homodimer of two identical brain-type CK-B subunits. BB-CK is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. There, CK-BB forms tightly coupled microcompartments for in situ regeneration of ATP that has been used up.

The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine or between phospho-creatine (PCr) and ADP. Its functional entity is a homodimer (CK-BB) in brain, smooth muscle as well as in other tissues and cells such as neuronal cells, retina, kidney, bone etc.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U813Hu01	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	MU813Hu22	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	PU813Hu01	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	KEU813Hu	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	KCU813Hu	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U813Mu01	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NPU813Mu01	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	PU813Mu01	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	KEU813Mu	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U813Ra01	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	MU813Ra21	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	PU813Ra01	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	KEU813Ra	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U813Ca01	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	PU813Ca01	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	LU813Ca71	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Creatine Kinase, Brain (CKB)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Creatine Kinase, Brain (CKB)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Creatine Kinase, Brain (CKB)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Creatine Kinase, Brain (CKB)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Creatine Kinase, Brain (CKB)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Creatine Kinase, Brain (CKB)	CLIA assay for Antigen Detection

Reference

"Human creatine kinase: isolation and sequence analysis of cDNA clones for the B subunit, development of subunit specific probes and determination of gene copy number."
Biochem. Biophys. Res. Commun. 144:1116-1127(1987) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of the human creatine kinase B gene."
Genomics 1:126-137(1987) [PubMed] [Europe PMC] [Abstract]

"Human creatine kinase-B complementary DNA. Nucleotide sequence, gene expression in lung cancer, and chromosomal assignment to two distinct loci."
J. Clin. Invest. 79:1412-1420(1987) [PubMed] [Europe PMC] [Abstract]

"Complete nucleotide sequence of the human creatine kinase B gene."
Nucleic Acids Res. 17:6385-6385(1989) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation of a functional human gene for brain creatine kinase."
J. Biol. Chem. 263:2442-2446(1988) [PubMed] [Europe PMC] [Abstract]

"Protein analysis of human maculae in relation to age-related maculopathy."
Lab. Invest. 73:267-272(1995) [PubMed] [Europe PMC] [Abstract]