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Growth Differentiation Factor 15 (GDF15)

PDF; MIC1; NAG-1; PLAB; PTGFB; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; Placental bone morphogenetic protein; Prostate differentiation factor

GDF15 is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.

Northern blot analysis showed that MIC1 is not expressed in undifferentiated cells but is progressively upregulated upon differentiation with retinoic acid followed by phorbol ester or cytokine treatment. Exposure of macrophages to MIC1 or TGFB1, followed by stimulation with lipopolysaccharide, suppressed the production of TNFA.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U809Hu01 Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies MU809Hu22 Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
PU809Hu01 Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
LU809Hu71 Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits KEU809Hu ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
KCU809Hu CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U809Mu01 Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
PU809Mu01 Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
LU809Mu81 FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits KEU809Mu ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
KCU809Mu CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins U809Ra01 Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies MU809Ra21 Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
PU809Ra01 Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits KEU809Ra ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
KCU809Ra CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection

Reference

"PLAB, a novel placental bone morphogenetic protein."
Biochim. Biophys. Acta 1354:40-44(1997) [PubMed] [Europe PMC] [Abstract]

"Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta."
J. Biochem. 122:622-626(1997) [PubMed] [Europe PMC] [Abstract]

"MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily."
Proc. Natl. Acad. Sci. U.S.A. 94:11514-11519(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family."
J. Biol. Chem. 273:13760-13767(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta."
Gene 203:17-26(1997) [PubMed] [Europe PMC] [Abstract]

"Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities."
Mol. Pharmacol. 59:901-908(2001) [PubMed] [Europe PMC] [Abstract]