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Growth Differentiation Factor 15 (GDF15)
Growth Differentiation Factor 15 (GDF15)
PDF; MIC1; NAG-1; PLAB; PTGFB; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; Placental bone morphogenetic protein; Prostate differentiation factor
GDF15 is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.
Northern blot analysis showed that MIC1 is not expressed in undifferentiated cells but is progressively upregulated upon differentiation with retinoic acid followed by phorbol ester or cytokine treatment. Exposure of macrophages to MIC1 or TGFB1, followed by stimulation with lipopolysaccharide, suppressed the production of TNFA.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Growth Differentiation Factor 15 (GDF15) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Growth Differentiation Factor 15 (GDF15) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Growth Differentiation Factor 15 (GDF15) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Growth Differentiation Factor 15 (GDF15) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Growth Differentiation Factor 15 (GDF15) CLIA assay for Antigen Detection
Reference
"PLAB, a novel placental bone morphogenetic protein." Biochim. Biophys. Acta 1354:40-44(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta." J. Biochem. 122:622-626(1997) [PubMed ] [Europe PMC ] [Abstract ]
"MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily." Proc. Natl. Acad. Sci. U.S.A. 94:11514-11519(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family." J. Biol. Chem. 273:13760-13767(1998) [PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta." Gene 203:17-26(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities." Mol. Pharmacol. 59:901-908(2001) [PubMed ] [Europe PMC ] [Abstract ]