Glucose Transporter 2 (GLUT2)

SLC2A2; SLC2-A2; Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver

SPN	U803
HGNC	11006
MGI	1095438
PubMed	9354798
RGD	3705
UniProt	P11168
Wiki	GLUT2

• Glucose transporter 2 (GLUT2) is a transmembrane carrier protein that enables passive glucose movement across cell membranes. It is the principal transporter for transfer of glucose between liver and blood, and for renal glucose reabsorption. In humans, this protein is encoded by the SLC2A2 gene.

• It has been proposed by genetics researchers in neonatal and maternal-fetal medicine at Harvard University Medical School and Beth-Israel Deaconess Hospital Medical Center, that this creates a problem for drug treated diabetic pregnancies in which glucose levels in the woman are uncontrolled, exposing her fetus to the possibility of neural tube and cardiac defects in the early-developing brain, spine, and heart.

Reference

"Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein."
Proc. Natl. Acad. Sci. U.S.A. 85:5434-5438(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus."
J. Clin. Endocrinol. Metab. 80:3131-3135(1995) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients."
Diabetologia 37:420-427(1994) [PubMed] [Europe PMC] [Abstract]

"A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity."
J. Biol. Chem. 269:17765-17767(1994) [PubMed] [Europe PMC] [Abstract]

"A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity."
Hum. Genet. 105:240-243(1999) [PubMed] [Europe PMC] [Abstract]

"Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome."
Pediatr. Res. 48:586-589(2000) [PubMed] [Europe PMC] [Abstract]