Farnesoid X Receptor (FXR)
NR1H4; BAR; FXR; HRR1; RIP14; Nuclear Receptor Subfamily 1,Group H,Member 4; Bile acid receptor; Farnesol receptor HRR-1; Retinoid X receptor-interacting protein 14
The farnesoid X receptor (FXR),is a nuclear hormone receptor with activity similar to that seen in other steroid receptors such as estrogen or progesterone but more similar in form to PPAR, LXR and RXR. FXR is encoded by the NR1H4 gene.
FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Like other steroid receptors, when activated, FXR translocates to the cell nucleus, forms a dimer (in this case a heterodimer with RXR) and binds to hormone response elements on DNA which elicits expression or transrepression of gene products.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U801Hu01 | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | MU801Hu22 | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| PU801Hu01 | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU801Hu | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U801Mu01 | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| PU801Mu01 | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU801Mu | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U801Ra01 | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | MU801Ra21 | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| PU801Ra01 | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU801Ra | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Farnesoid X Receptor (FXR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Farnesoid X Receptor (FXR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Farnesoid X Receptor (FXR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Farnesoid X Receptor (FXR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Farnesoid X Receptor (FXR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Farnesoid X Receptor (FXR) | CLIA assay for Antigen Detection |
Reference
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Gene 290:35-43(2002) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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Science 284:1362-1365(1999) [PubMed] [Europe PMC] [Abstract]
"Bile acids: natural ligands for an orphan nuclear receptor."
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Genes Dev. 17:1581-1591(2003) [PubMed] [Europe PMC] [Abstract]
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Mol. Cell. Biol. 23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]
"Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1."
J. Biol. Chem. 279:54348-54357(2004) [PubMed] [Europe PMC] [Abstract]
"Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes."
Am. J. Physiol. 302:G937-G947(2012) [PubMed] [Europe PMC] [Abstract]
"A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR."
Mol. Cell 11:1079-1092(2003) [PubMed] [Europe PMC] [Abstract]
"Structural basis for bile acid binding and activation of the nuclear receptor FXR."
Mol. Cell 11:1093-1100(2003) [PubMed] [Europe PMC] [Abstract]
"Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064."
Bioorg. Med. Chem. Lett. 18:4339-4343(2008) [PubMed] [Europe PMC] [Abstract]
"Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation."
Proc. Natl. Acad. Sci. U.S.A. 105:5337-5342(2008) [PubMed] [Europe PMC] [Abstract]
"Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064."
Bioorg. Med. Chem. Lett. 19:2969-2973(2009) [PubMed] [Europe PMC] [Abstract]
"FXR agonist activity of conformationally constrained analogs of GW 4064."
Bioorg. Med. Chem. Lett. 19:4733-4739(2009) [PubMed] [Europe PMC] [Abstract]
"Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)."
J. Med. Chem. 52:904-907(2009) [PubMed] [Europe PMC] [Abstract]
"Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates."
J. Med. Chem. 53:1774-1787(2010) [PubMed] [Europe PMC] [Abstract]