Retinoid X Receptor Alpha (RXRa)
NR2B1; RXR-A; NR2-B1; Nuclear Receptor Subfamily 2,Group B,Member 1; Retinoic acid receptor RXR-alpha
Retinoid X receptor alpha (RXR-alpha), is a nuclear receptor.Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors.
This receptor differs from the other 3 RARs within the ligand-binding domain and is incapable of high affinity binding of retinoic acid itself. The retinoic acid, thyroid hormone, and vitamin D receptors, as well as the retinoid X receptor, activate transcription from response elements containing 2 or more degenerate copies of the consensus motif AGGTCA.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU800Hu01 | Recombinant Retinoid X Receptor Alpha (RXRa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU800Hu01 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IP. |
| PAU800Hu01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU800Hu01 | CLIA Kit for Retinoid X Receptor Alpha (RXRa) | CLIA assay for Antigen Detection |
| ELU800Hu01 | ELISA Kit for Retinoid X Receptor Alpha (RXRa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU800Mu01 | Recombinant Retinoid X Receptor Alpha (RXRa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU800Mu01 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IP. |
| PAU800Mu01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU800Mu01 | CLIA Kit for Retinoid X Receptor Alpha (RXRa) | CLIA assay for Antigen Detection |
| ELU800Mu01 | ELISA Kit for Retinoid X Receptor Alpha (RXRa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU800Ra01 | Recombinant Retinoid X Receptor Alpha (RXRa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU800Ra01 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IP. |
| PAU800Ra01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU800Ra01 | CLIA Kit for Retinoid X Receptor Alpha (RXRa) | CLIA assay for Antigen Detection |
| ELU800Ra01 | ELISA Kit for Retinoid X Receptor Alpha (RXRa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU800Ca01 | Recombinant Retinoid X Receptor Alpha (RXRa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU800Ca01 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IP. |
| PAU800Ca01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU800Ca01 | CLIA Kit for Retinoid X Receptor Alpha (RXRa) | CLIA assay for Antigen Detection |
| ELU800Ca01 | ELISA Kit for Retinoid X Receptor Alpha (RXRa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU800Po01 | Recombinant Retinoid X Receptor Alpha (RXRa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU800Po01 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IP. |
| PAU800Po01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU800Po01 | CLIA Kit for Retinoid X Receptor Alpha (RXRa) | CLIA assay for Antigen Detection |
| ELU800Po01 | ELISA Kit for Retinoid X Receptor Alpha (RXRa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU800Bo01 | Recombinant Retinoid X Receptor Alpha (RXRa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU800Bo01 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IP. |
| PAU800Bo01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU800Bo01 | CLIA Kit for Retinoid X Receptor Alpha (RXRa) | CLIA assay for Antigen Detection |
| ELU800Bo01 | ELISA Kit for Retinoid X Receptor Alpha (RXRa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU800Rb01 | Recombinant Retinoid X Receptor Alpha (RXRa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU800Rb01 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IP. |
| PAU800Rb01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU800Rb01 | CLIA Kit for Retinoid X Receptor Alpha (RXRa) | CLIA assay for Antigen Detection |
| ELU800Rb01 | ELISA Kit for Retinoid X Receptor Alpha (RXRa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU800Mo01 | Recombinant Retinoid X Receptor Alpha (RXRa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU800Mo01 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IP. |
| PAU800Mo01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU800Mo01 | CLIA Kit for Retinoid X Receptor Alpha (RXRa) | CLIA assay for Antigen Detection |
| ELU800Mo01 | ELISA Kit for Retinoid X Receptor Alpha (RXRa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Nuclear receptor that identifies a novel retinoic acid response pathway."
Nature 345:224-229(1990) [PubMed] [Europe PMC] [Abstract]
"DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system."
FEBS Lett. 582:2737-2744(2008) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"9-cis retinoic acid is a high affinity ligand for the retinoid X receptor."
Cell 68:397-406(1992) [PubMed] [Europe PMC] [Abstract]
"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."
Cell 90:569-580(1997) [PubMed] [Europe PMC] [Abstract]
"A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."
J. Biol. Chem. 274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]
"Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR."
Mol. Cell. Endocrinol. 147:37-47(1999) [PubMed] [Europe PMC] [Abstract]
"Serine 27, a human retinoid X receptor alpha residue, phosphorylated by protein kinase A is essential for cyclicAMP-mediated downregulation of RXRalpha function."
Biochem. Biophys. Res. Commun. 279:853-857(2000) [PubMed] [Europe PMC] [Abstract]
"PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors."
Mol. Cell. Biol. 21:2298-2311(2001) [PubMed] [Europe PMC] [Abstract]
"Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity."
Hepatology 35:937-946(2002) [PubMed] [Europe PMC] [Abstract]
"Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha."
J. Biol. Chem. 277:28624-28630(2002) [PubMed] [Europe PMC] [Abstract]
"ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor."
Biochem. Biophys. Res. Commun. 317:54-59(2004) [PubMed] [Europe PMC] [Abstract]
"The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity."
J. Biol. Chem. 279:18926-18934(2004) [PubMed] [Europe PMC] [Abstract]
"9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway."
J. Biol. Chem. 281:15394-15404(2006) [PubMed] [Europe PMC] [Abstract]
"Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1."
J. Biol. Chem. 281:30669-30677(2006) [PubMed] [Europe PMC] [Abstract]
"Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function."
Mol. Cell. Proteomics 6:677-688(2007) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors."
Mol. Pharmacol. 76:1360-1369(2009) [PubMed] [Europe PMC] [Abstract]
"Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling."
Endocrinology 151:2361-2372(2010) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix."
Eur. J. Biochem. 224:639-650(1994) [PubMed] [Europe PMC] [Abstract]
"Structural determinants of nuclear receptor assembly on DNA direct repeats."
Nature 375:203-211(1995) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha."
Nature 375:377-382(1995) [PubMed] [Europe PMC] [Abstract]
"High-resolution solution structure of the retinoid X receptor DNA-binding domain."
J. Mol. Biol. 281:271-284(1998) [PubMed] [Europe PMC] [Abstract]
"Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1."
EMBO J. 19:1045-1054(2000) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid."
EMBO J. 19:2592-2601(2000) [PubMed] [Europe PMC] [Abstract]
"Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix."
Genes Dev. 14:2229-2241(2000) [PubMed] [Europe PMC] [Abstract]
"Structural basis of RXR-DNA interactions."
J. Mol. Biol. 296:509-520(2000) [PubMed] [Europe PMC] [Abstract]
"Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors."
Mol. Cell 5:545-555(2000) [PubMed] [Europe PMC] [Abstract]
"Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors."
Proc. Natl. Acad. Sci. U.S.A. 98:13919-13924(2001) [PubMed] [Europe PMC] [Abstract]
"The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization."
Mol. Cell 16:893-905(2004) [PubMed] [Europe PMC] [Abstract]