Fibroblast Growth Factor Receptor Substrate 2 (FRS2)
SNT1; FRS2A; FRS2Alpha; SNT; SNT-1; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1
The deduced 508-amino acid protein has a predicted molecular mass of 56.8 kD. It contains a myristylation sequence, a phosphotyrosine-binding (PTB) domain, and 4 potential GRB2-binding sites. Northern blot analysis of adult mouse tissues detected ubiquitous expression of Frs2, with highest levels in brain, kidney, lung, ovary, and testis. SDS-PAGE showed that FRS2 migrates as doublet of 92 to 95 kD.
Melillo et al. (2001) presented evidence that FRS2 couples both ligand-regulated and oncogenic forms of RET with the MAPK signaling cascade under normal biologic conditions and pathologic conditions, such as multiple endocrine neoplasias and papillary thyroid carcinomas.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU781Hu01 | Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU781Hu01 | Monoclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IP. |
| PAU781Hu01 | Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU781Hu01 | CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | CLIA assay for Antigen Detection |
| ELU781Hu01 | ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU781Mu01 | Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU781Mu01 | Monoclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IP. |
| PAU781Mu01 | Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU781Mu01 | CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | CLIA assay for Antigen Detection |
| ELU781Mu01 | ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU781Ra01 | Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU781Ra01 | Monoclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IP. |
| PAU781Ra01 | Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU781Ra01 | CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | CLIA assay for Antigen Detection |
| ELU781Ra01 | ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU781Ca01 | Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU781Ca01 | Monoclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IP. |
| PAU781Ca01 | Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU781Ca01 | CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | CLIA assay for Antigen Detection |
| ELU781Ca01 | ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU781Po01 | Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU781Po01 | Monoclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IP. |
| PAU781Po01 | Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU781Po01 | CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | CLIA assay for Antigen Detection |
| ELU781Po01 | ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU781Bo01 | Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU781Bo01 | Monoclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IP. |
| PAU781Bo01 | Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU781Bo01 | CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | CLIA assay for Antigen Detection |
| ELU781Bo01 | ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU781Rb01 | Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU781Rb01 | Monoclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IP. |
| PAU781Rb01 | Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU781Rb01 | CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | CLIA assay for Antigen Detection |
| ELU781Rb01 | ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU781Mo01 | Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU781Mo01 | Monoclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IP. |
| PAU781Mo01 | Polyclonal Antibody to Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU781Mo01 | CLIA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | CLIA assay for Antigen Detection |
| ELU781Mo01 | ELISA Kit for Fibroblast Growth Factor Receptor Substrate 2 (FRS2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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J. Biol. Chem. 274:9861-9870(1999) [PubMed] [Europe PMC] [Abstract]
"EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2."
Biol. Chem. 384:1215-1226(2003) [PubMed] [Europe PMC] [Abstract]
"TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma."
Cancer Cell 6:347-360(2004) [PubMed] [Europe PMC] [Abstract]
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FEBS Lett. 581:727-734(2007) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
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EMBO J. 30:3259-3273(2011) [PubMed] [Europe PMC] [Abstract]
"Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins."
Cancer Sci. 99:1319-1325(2008) [PubMed] [Europe PMC] [Abstract]
"Fibroblast growth factor signalling: from development to cancer."
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors."
Mol. Cell 6:921-929(2000) [PubMed] [Europe PMC] [Abstract]