Interleukin 24 (IL24)

C49A; FISP; IL10B; MDA7; Mob-5; ST16; Mda-7; Melanoma Differentiation Association Protein 7; Suppression Of Tumorigenicity 16

SPN	U780
HGNC	11346
MGI	2135548
PubMed	15667561
RGD	621484
UniProt	Q13007
Wiki	Interleukin_24

Interleukin 24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as Melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called Stat-1 and Stat-3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 cells  and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer. Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24.

Reference

"Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression."
Oncogene 11:2477-2486(1995) [PubMed] [Europe PMC] [Abstract]

"Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties."
Oncogene 20:7051-7063(2001) [PubMed] [Europe PMC] [Abstract]

"Loss of novel mda-7 splice variant (mda-7s) expression is associated with metastatic melanoma."
J. Invest. Dermatol. 123:583-588(2004) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing of IL-24 in melanocytes by deletion of exons 3 and 5."
Int. J. Immunogenet. 32:375-378(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice."
Proc. Natl. Acad. Sci. U.S.A. 95:14400-14405(1998) [PubMed] [Europe PMC] [Abstract]

"Critical role of lysine 123 in the ubiquitin-mediated degradation of MDA-7/IL-24."
J. Interferon Cytokine Res. 32:575-582(2012) [PubMed] [Europe PMC] [Abstract]