Hyaluronan Mediated Motility Receptor (HMMR)

CD168; RHAMM; IHABP; RHAMM; Intracellular hyaluronic acid-binding protein

SPN	U779
HGNC	5012
MGI	104667
PubMed	19064580
RGD	2805
UniProt	O75330
Wiki	HMMR

RHAMM) was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan,RHAMM is less well studied than the main hyaluronan (HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum / Golgi complex, RHAMM does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence.

RHAMM normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of RHAMM to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis.

Reference

"The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains."
Gene 174:299-306(1996) [PubMed] [Europe PMC] [Abstract]

"The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells."
J. Cell Sci. 111:1685-1694(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]